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《China Journal of Traditional Chinese Medicine and Pharmacy》 2000-01
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Effects of Kidney-Supplementing Spleen-Invigorating Blood Stasis-Removing Recipe on Immune Function and Free Radical Metabolism in Old Mice

Li Zhixin(Deparment of Integrated Traditional Chinese and Western Medicine, Beijing Medical University, Beijing)  
In order to verify the reliability and reasonability of the theory that "deficiency of Zhenqi complicated with blood stasis is the main cause/mechanism of aging, the effect of the kidney-supplementing spleen-invigorating blood stasis-removing recipe on immune function, free radical metabolism in old mice was studied. After old mice were medicated with decoction for 4 weeks, interleukin-2 (IL-2) production of splenic lymphocytes, interleukin-1 (IL-1) production of peritoneal macrophages, SOD, CAT and GSH-Px activities in ery-throcites. LPO contents in liver brain were detected. The activities of IL-1, Il-2, SOD, CAT and GSH-Px in old mice were significantly lower than those in the young mice, and LPO contents in liver and brain were higher. After administration, the above-mentioned indexes were obviously improved. The old organism really exists the constitution of "deficiency" and "stasis", and further provides and experimental basis for our viewpoint . Meanwhile the decrease of IL-2 production was closely related with the function of macrophage and free radical metabolism, besides lower function of T lymphocyte.
【CateGory Index】: R285
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