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《China Journal of Traditional Chinese Medicine and Pharmacy》 2001-05
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Effect of Nao Er Kang on Learning and Memory Disorders in Model Rats with Alzheimer's Diseases

Li Xi( Second Affliated Hospital of Xi' an medical University, Xi' an )  
Objective: To observe the protective effect of Nao Er Kang on learning and memory disorders in model rats with Alzheimer's disease (AD) caused by aluminum chloride and to discuss Nao Er Kang effect on content of M-receptor. Methods: After administered of different drugs in different proups, rats were given training of step down test. Simutaneously,the latency period and error times were recorded,the learning results were observed 24 hours later. Others were rapidly decollated and brains were fetched, the contents of M-receptor subtypes were observed. Compared with control group, the memory's latency period in model group largely shortened(p 0.01)and learning latency period prolonged obviously. In addition, the error times of learning and memory increased (p 0.01) .In medicated group, the memory' s latency period obviously prolonged (p 0.01) and learning latency period obviously shortened( p0.05 orp0.01). The error times of learning and memory in three medicated groups of Nao Er Kang shortened (p 0.05).But there was no significant difference in three groups of Nao Er kang. The contents of M1 -receptor subtypes in the cortex and hippocampus of rats were largely improved except small dose group, but the contents of M2-receptor subtypes were no significant difference in these two areas. Conclusions: 1.Nao Er Kang can protect rats from learning and memory disorders. 2.Nao Er Kang can largely increase the content of M1-receptor in cortex and hippocampas in AD rats.
【Fund】: 陕西省“九五”科技攻关课题
【CateGory Index】: R285
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