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《China Journal of Traditional Chinese Medicine and Pharmacy》 2003-03
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Experimental Research of Action of Aloe Extracts on Anti-free Radical Oxidation Damage DNA in Senile Model Rats

Lv Mingzhuang et al (The Affiliated Hospital of Guiyang Medical College)  
Objective: To explore the efficacy and its possible mechanism of aloe retarding senility. Methods: Senile model was made by which mice inhale ozone, treating measures of extracted liquid of aloe in different concentration was taken to administer those model mice in the course of model-making. The activity of blood SOD and the amount of MDA in liver tissue were tested and Comet Assay was applied to measure the degree of oxidation damage of cell DNA of liver and spleen tissue 9 weeks later. Results: The blood SOD activity and the amount of MDA in liver tissue were markedly higher and the length of liver and spleen cell DNA tailing was shortened in the group of mice treated by aloe extracts compared with control group. Aloe extracts efficaciously relieve the degree of liver and spleen cell DNA damage and its action is more comprehensive than Compositus Danshen tablets in the control group. Conclusion: Aloe can retard senility by which increases the capability of body anti-oxidation of free radical and relieves the damage degree of liver and spleen cell DNA.
【Fund】: 贵州省科委基金资助
【CateGory Index】: R285
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