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《China Journal of Traditional Chinese Medicine and Pharmacy》 2003-03
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Experimental Research of Action of Aloe Extracts on Anti-free Radical Oxidation Damage DNA in Senile Model Rats

Lv Mingzhuang et al (The Affiliated Hospital of Guiyang Medical College)  
Objective: To explore the efficacy and its possible mechanism of aloe retarding senility. Methods: Senile model was made by which mice inhale ozone, treating measures of extracted liquid of aloe in different concentration was taken to administer those model mice in the course of model-making. The activity of blood SOD and the amount of MDA in liver tissue were tested and Comet Assay was applied to measure the degree of oxidation damage of cell DNA of liver and spleen tissue 9 weeks later. Results: The blood SOD activity and the amount of MDA in liver tissue were markedly higher and the length of liver and spleen cell DNA tailing was shortened in the group of mice treated by aloe extracts compared with control group. Aloe extracts efficaciously relieve the degree of liver and spleen cell DNA damage and its action is more comprehensive than Compositus Danshen tablets in the control group. Conclusion: Aloe can retard senility by which increases the capability of body anti-oxidation of free radical and relieves the damage degree of liver and spleen cell DNA.
【Fund】: 贵州省科委基金资助
【CateGory Index】: R285
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【References】
Chinese Journal Full-text Database 7 Hits
1 Zhang Li , Zhang Ling (Beijing University of TCM; Jilin Encephalopathy Hospital);Effects of Combination of Acupuncture and Herbal Medicine on Praxiology and Brain Injury in Rat with Repetitive Temporary Cerebral Ischaemia-Reperfusion Injury[J];China Journal of Traditional Chinese Medicine and Pharmacy;2004-05
2 LIN Wen-tao,CHEN Jing-gang,WENG Xi-quan,et al.(Guangzhou Institute of Physical Education,Guangzhou510075,China);Effect of Aerobic Exercise and Aloe on Anti-oxygenized Enzyme Activity in the Liver of Diabetic Rats[J];Journal of Guangzhou Physical Education Institute;2005-06
3 XU Zheng-zhe1,CHEN Zheng-ai2 (1.Department of Thoracic and Cardiac Surgery,Affiliated Hospital of Yanbian University;2.Department of Pharmacology,Yanbian University College of Basic Medicine:Yanji 133000,Jilin,China);Protective effects of capsules of the Chinese aloe flower powder for senile in rats[J];Journal of Medical Science Yanbian University;2007-04
4 Cui Wei1,2,Lou Jianshi1 (1.Department of Pharmacology,Tianjin Medical University,Tianjin ,China 300070; 2.Department of Pharmacology,Tianjin Municipol People's Hospitol,Tianjin,China 300121);Status of Pharmacology Research of Aloe[J];China Pharmaceuticals;2007-16
5 JING Xue-an,ZONG Chuan-long,ZHANG Xian-zhong,et al.Department of Basic Medicine,Taishang Medical University(Taian 271000,China);Antagonistic effects of sodium selenite,vitamin E and C on DNA damage[J];Chinese Journal of Public Health;2008-10
6 WAN Jin-zhi XU Xin-jun LUO Xuan FANG Wei FANG Zi-sheng (School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510089,China);The genotoxicity of the Aloe extract primarily evaluated by micronucleus test[J];Chinese Journal of New Drugs;2008-11
7 He Ailing Kaifeng Hospital of Traditional Chinese Medicin,Henan Province,Kaifeng(475000);Recent Research on Pharmacological Action of Aloe[J];Chinese Medicine Modern Distance Education of China;2009-06
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Meng Ziqing1,Zhang Lianzhen21Division of Environmental Biological Toxicology and Department of Life Sciences,Shanxi University(taiyuan 030006)2China Institute for Radiation Protection;PRINCIPLE AND METHOD OF COMET ASSAY TO STUDIES DNA DAMAGE IN MAMMALLIAN CELLS[J];CHINA PUBLIC HEALTH;1998-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Zun-zhen, HENG Zheng-chang, LIAO Yan, ZHAO Rong (Department of Environment Health, West China University of Medical Sciences, Chengdu 610041,China);STUDY ON DNA DAMAGE INDUCED BY INDIRECT MUTAGENS USING COMET ASSAY IN TESTICULAR CELLS IN VITRO[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-01
2 YANG Jian - yi , LI Li , PENG Yun , et al ( Shanxi Medical University, Taiyuan 030001, China);DNA Damage Caused by low Dose Methotrexate and Protective Effect of Folinic acid[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-01
3 YANG Jian-yi,PENG Yun,LI Li,DU Sheng-jia,SHAN Lian-zhe,ZHANG Xin-wang,WANG Wen-juan(School of Basic Medical Science,Shanxi Medical University,Taiyuan030001,Shanxi,China);Detection of DNA Damage Induced by Methotrexate in Multiple Mouse Organs Using SCGE Assay[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-05
4 ZHANG Zun-zhen, ZHANG Qin, WU Mei, LI Na,HENG Zheng-chang(Department of Environmental Health, School of Public Health, Sichuan University, Chengdu 610041, Sichuan,China.);Preliminary Study on the Effect of Down-regulated hOGG1 Gene Expression on DNA Damage and Repair[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-03
5 Zhao Ying, Wang Zhi-qiang, Yang Zhi-ping, Wang Wei, Huang Xiao-mu (Anhui Center for Disease Control and Prevention ,Hefei,Anhui,230061,China);Initial Observation on DNA Trauma of Fish Red Blood Cell Caused by organic distill from Chaohu Lake[J];Anhui Journal of Preventive Medicine;2003-03
6 LI Jian-xiong,ZHANG Yan,TANG Xiao-jun,CHI Jian-wei (Agro-biotech Research Institute,Guangdong Academy of Agricultural Sciences,Guangzhou510640,China);Processing Technology of Whole Aloe Flesh Instant Solid Beverage[J];Storage and Process;2004-05
7 WU Ting~1,WANG Chao~2,LI Jie~1,LI Nan~1(1.College of Science,China Agricultural University,Beijing 100094,China;2.Chinese Academy of Inspection and Quarantine,Beijing 100025,China);Determination of anthraquinone-compound in cosmetics by high performance liquid chromatography[J];China Surfactant Detergent & Cosmetics;2006-01
8 YE Rong, LIN Xin\|hua, LUO Hong\|bin (Division of Pharmaceutical, Fujian Medical University, Fuzhou\ 350004, China) \ \;The Electrode Reaction Mechanism and Anodic Stripping Voltammetry Determination of Zinc(Ⅱ) in Aloe vera[J];Journal of Fujian Medical University;2002-04
9 DENG Jun wen( The University Journal Editing Division, Foshan University, Foshan 528000 ,China);The chemical compositions of Aloe and its pharmacological action[J];JOURNAL OF FOSHAN UNIVERSITY(NATURAL SCIENCE EDITION);2000-02
10 TANG Zhi-hua(Shanxi University of Technology,Shanxi Hanzhong 723000,China);Trace Element Arsenic and Health[J];Trace Elements Science;2003-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Du Yangyang and Mo ZiyaoGuangzhou Anti-epidemic Station,Guangzhou 5l0080;STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC POTEN-TIALS OF GYPENOSIDES(GPS)IN MICE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1995-03
2 Ma Fei1,2 Li Yubao2* Pei Lanying2 Lu Jianbiao2 (1College of Life Science,Shandong Normal University,Jinan,250014,China;2College of Agriculture,Liaocheng University,Liaocheng,252059,China);Effect of Milkvetch on Broiler Immunity[J];Anhui Agricultural Science Bulletin;2007-05
3 ZHU Li-cheng et al (College of Life Sciences,Jinggangshan University,Jian,Jiangxi 343009);Study on the Anti-fungi Activity of the Extract from Three Kinds of Chinese Herb.[J];Journal of Anhui Agricultural Sciences;2006-21
4 LI Hai quan (Dept of Phar, The First Affiliospital of Anhui College of Traditional Chinese Medicine, Hefei 230031,China);Research of achyranthes bidentata polysaccharides on hypoglycemic effect in experimental diabetic mice[J];Anhui Medical and Pharmaceutical Journal;2004-05
5 LIU Xia,WANG Ping-jun,Xu Fu-xin (The Frist People's Hospital of Wuhu,Anhui Wuhu 241000,China);STUDY ON GYPENOSIDES INHIBITING NEOPLASM GROWTH AND ELEVATING IMMUNOLOGICAL FUNCTION IN LEWIS LUNG CANCER OF MICE[J];Journal of Anhui Traditional Chinese Medical College;2001-01
6 GUO Jia, WANG Lei, ZHANG Li, YUAN Hong (Department of Traditional Chinese Medicine,the Third Hospital, Beijing University, Beijing 100083, China);Effect of Electro-acupuncture Preconditioning on Free Radical Content in Brain of Rats with Cerebral Ischemia Reperfusion[J];Journal of Anhui Traditional Chinese Medical College;2003-01
7 JIANG Ying li, SONG Jin dan* Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110001, P.R.China;Apoptotic Induction of Xinjiang Shikonin on Human Colorectal Cancer CCL229 Cell[J];Chinese Journal of Cancer;2001-12
8 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
9 ZHANG Yu-jiang, WANG Mei-zhi, ZHANG Hai-ping, et al (Department of Adult Education, Qingdao University Medical College, Qingdao 266021, China);;INHIBITORY EFFECTS OF POLYPEPTIDE FROM CHLAMYS FARRERI ON THE EXPRESSIONS OF P53 PROTEIN, EGFR AND SUBSTANCE P IN HAIRLESS MICE SKIN AFTER CHRONIC UVB IRRADIATION[J];Acta Acadimae Qingdao Umvesitatis;2004-02
10 Zhao Jihong 1) Liang Yu 2) Yan dayu 2) (1)College of Basic Sci., North China Univ. of Tech., 100041, Beijing, China 2) Graduate School of Univ. of Sci. &Tech. of China, 100039, Beijing, China);Structure-Antioxidation Relationship of Flavonoid Antioxidants[J];Journal of North China University of Technology;2001-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 GUO Sheng-wei,BI Xiao-lin,CHEN Lei,GU Zhen-xin(Nanjing University of Traditional Chinese Medicine,Jangsu Nanjian 210029,China);Determination of the Trace Elements in Leaves of Aloe Vera L.Var.Chinese(Haw.) Berg by Flame Atomic Absorption Spectrometry[J];Journal of Anhui Traditional Chinese Medical College;2005-06
2 Zhang Minghao1) Cui Lihua2) Chen Zhenghua3)(1)College of Life Sciences,Beijing Normal University,100875,Beijing,China;2)Beijing Normal University Library,100875,Beijing,China;3)Postdoctoral Scientific Research Station of Gansu Yasheng Industrial(Group) Co.,Ltd.,100101,Beijing,China);RESEARCH ON EXPRESSED SEQUENCE TAGS OF THE SIXTH CHROMOSOME FROM ALOE VERA[L.] BURM.F[J];Journal of Beijing Normal University(Natural Science);2007-05
3 LIU An-jun MENG Yan-li CAO Dong-xu WANG Wei-jun (College of Food Engineering & Biotechnology,Tianjin University of Science & Technology,Tianjin 300457,China);Study on Differential Expressions of Liver Tissue Proteins in the Alloxan-Induced Hepatic Injury in Mice[J];Modern Food Science and Technology;2007-09
4 WANG Jin-li~(1),ZHANG Tao~(1),REN Li-ping~(1),XU Gong-da~(1),ZHANG Chun-rong~(1),YU Jin-lian~(2)(1.Department of Chemistry,College of Science,China Agricultural University,Beijing 100094,China;2.Department of Environmental Science and Engineering,Shanghai Normal University,Shanghai 200234,China);Determination of Germanium in A.Arborescens by Fluorospectrophotometry with Morin[J];;2005-12
5 Chen Liyan Liu Junxing Shi Xiaoguang Key Laboratory of Forest Plant Ecology,Northeast Forestry University (Harbin,150040) Heilongjiang province Pharmaceutical Industry Company (Harbin,150000) College of basic medicine,Jiamusi University (Jiamusi,154007);Experimental study on the Anti-aging Effects of Decoction of Four Noble Drugs[J];Heilongjiang Medicine Journal;2006-05
6 LU Chaoguo1),WANG Hongzhuan2),LI Yanhong1),LIU Guoji1),LUO Tingliang1) 1)Institute of Chemical Engineering,Zhengzhou University,Zhengzhou 450001 2)Nylon 66 Salt Company of China Shenma Group,Pingdingshan 467013;Simultaneous determination of Aloin and Aloe-emodin in Aloe by HPLC[J];Journal of Zhengzhou University(Medical Sciences);2008-03
7 CAO Hua,FENG Xian-qiong,YANG Rong,et al.;Aloe for the Prevention of Mannitol-induced Phlebitis[J];West China Medical Journal;2008-02
8 Guan Huilin et al(Mudanjiang Medical College Heilongjiang Mudanjiang 157011);EFFECT OF ALOE EXTRACTS ON ISOLATED GASTROCNEMIUS FATIGUE INDUCED BY ELECTRIC STIMULATION IN TOAD[J];Journal of Mudanjiang Medical College;2008-04
9 YE Jin-feng1,LIU Xian-hui1,HUANG Zhuo-ling1,LI Jiang-bin2,HOU Gan2.1.Institute of Laboratory Medicine,Guangdong Medical College;2.Department of Clinical Chemistry of the Institute of Laboratory Medicine,Dongguan,Guangdong523808 China;Study on the antifatigue effect of aloe barbadensis polysaccharide[J];Laboratory Medicine and Clinic;2009-22
10 LIANG Jian, HE Li, YANG Jun-feng, et al. (Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, Guangxi, P. R. China);Study on the effect of moving bowel of a traditional Chinese medicine[J];China Tropical Medicine;2008-08
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Meng Ziqiang Department of Environmental Sciences, Shanxi University, Taiyuan;RADIATION-INDUCED DNA SINGLE STRAND BREAKS AND THEIR REJOINING IN MAMMALIAN CELLS BY HYDROXYLAPATITE CHROMATOGRAPHY[J];Journal of Radiation Research and Radiation Processing;1987-04
2 Meng Ziqiang (Department of Environmental Sciences,Shanxi University,Taiyuan) Zhang Lianzheng (Institute for Radiation Protection,MNI);A METHOD FOR DETERMINATION OF STRAND SEPARATION RATE OF DNA IN ALKALI AND ITS USE INDNA DAMAGE STUDY[J];Acta Scientiae Circumstantiae;1988-01
3 Yuan Axing; Kang Shuhua; Qin Ling; et al (Guangxi Institute of Traditional Chinese Medicine and Materia Medica,Nanning);Stndies on the Chemical Constituents of the Leaves of Chinese Aloe (Aloe vera var Chinensis)[J];Chinese Traditional and Herbal Drugs;1994-07
4 Yuan Axing, Kang Shuhau, Qin Ling, Ruan Bin Fan Yijun (Guangxi Institute of Traditional Chinese Medical and Pharmaceutical Sciences Nanning 530022);Isolation and Identification of Aloesin from the L(?)aves of Aloe vera L. var. chinensis (Haw.) Berger[J];China Journal of Chinese Materia Medica;1991-05
5 Chen Sheng,Feng Jiade,YU Tianwei,et al National Institute for Occupational Safety and Health ,Ministry of Labour,Beijing 100029;ABSTRACTS OF ORIGINAL ARTICLES IN ENGL ISH STUDY ON DNA DAMAGE OF LYMPHOCYTES IN WORKERS EXPOSED TO HEAT,CARBON MONOXIDE AND DUST[J];CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND DCCUPATIONAL DISEASES;1995-06
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