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《China Journal of Traditional Chinese Medicine and Pharmacy》 2006-04
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Effect of GETO on Learning and Memory of Experiment AD Model Rats and Its Mechanism

Xu Yi~(1) Tian Jinzhou~(1) Sheng Shuli~(2) Shi Jing~(1) Ji Zhijuan~(2) Yin Junxiang~(1) Zhao Zhiwei~(2)(~(1)Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100700;~(2)Beijing Xuanwu Hospital,Capital University of Medical Sciences,Beijing 100053)  
Objective: To observe the effect of GETO on learning and memory of experiment AD model rats and search its cholinergic mechanism of action.Methods: β-amyloid protein(Aβ_(1-42)) injection into hippocampus in rat was applied to make experimental rat model of AD.Morris water maze test were employed to investigate the function of learning and memory in AD model rats after 4 weeks,and immunohistochemical stain was done with Choline Acetyltransferase(ChAT) and nerve growth factor(NGF) antibodies after Morris water maze test,and system of image pro-plus were used to gain the number and grey degree of positive neurons.Results: In Morris water maze test: The mean escape latent period of the Model rats obviously prolonged than that of the Normal rats,the number of traversing flat roof obviously decreased.The mean escape latent period and the number of traversing flat roof of the GETO rats significantly shorten than the model rats.Immunohistochemical test: The number of positive staining neuron in hippocampus CA1 of ChAT and NGF in the GETO rats was not significantly different from those in the Normal rats and the Donepezil rats,but significantly different from those in Model rats with injection of Aβ_(1-42)(P0.01).Conclusion: GETO can markedly improve the function of learning and memory of rats of AD model induced by Aβ_(1-42),and its mechanism of action may be associated with improving expression of ChAT and NGF,and maintain cholinergic nerve function.
【Fund】: 教育部科学技术研究重大项目(10408);; 国家重点基础研究发展计划(973计划)项目(No.2003CB517104);; 长江学者奖励计划资助
【CateGory Index】: R285.5
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