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《China Journal of Traditional Chinese Medicine and Pharmacy》 2007-05
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Effects of Gross Polysaccharide of Radix Rehmanniae Preparata on Morphology Changes of Thymus and Spleen in Blood Deficiency Model Mice

Miao Mingsan Sun Yanhong Shi Jingjing Liu Huili(Henan College of Traditional Chinese Medicine,Zhengzhou 450008)  
Objective: To probe the effects of gross polysaccharide of Radix Rehmanniae Preparata(GPRRP) on the morphology changes of immune organ of blood deficiency model mice.Methods: Using the blood deficiency mice models induced by releasing blood and injection of Cyclophosphamide as the experimental objects,the model animals were divided into 5 groups,that was the large,middle and small dose of GPRRP groups,Danggui Buxue Oral Liquid group,model group,at the same time,giving a blank control group.It was given successively relating drugs to the animals of several groups for 10 days.At the end of the experiment,the hemogram was measured and the thymus and spleen were taken,and making pathological section,then these tissues morphology changes were observed under microscope.Results: GPRRP can obviously resist the atrophy of thymus and spleen induced by the model establishing,can obviously increase the depth of thymus cortex and the number of cortex cells,can enlarge the size of spleen nodules and obviously increase the number of lymphocyte.Conclusion: GPRRP can resist the atrophy of thymus and spleen in blood deficiency model mice.
【Fund】: 教育部世纪优秀人才支持计划(No·NCET-04-0657);; 河南省高等学校创新人才培养工程(No.2004-23)
【CateGory Index】: R285
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