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《China Journal of Traditional Chinese Medicine and Pharmacy》 2007-06
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Effect of Tongluo Jiunao Oral Solution on Learning and Memory and the Expression of AChE in Hippocampus of AD Rats

Zhang Xiaojie1,2 Niu Yingcai1 Xing Guihua1 Lin Chunrong1 Li Xueyan1 Li Pengtao2 (1 Institute of Pharmaceutical Research,Qiqihaer College of Traditional Chinese Medicine,Qiqihaer,161042;2 Basic Medical College,Beijing University of Traditional Chinese Medicine,Beijing 100029)  
Objective: To observe the effect of Tongluo Jiunao oral solution on learning and memory and the expression of AChE in hippocampus of AD rats induced by β-amyloid1-40.Methods: 140 SD rats were divided into blank control group(normal group),pseudo-operation control group,negtive control group(model group),positive control group and experiment group(48、24、12mg·kg-1·d-1)at random.The model of AD were established by injecting β-amyloid1-40 into bilateral hippocampus.After 4 weeks,Morris Water Maze was used to determine the ability of learning and memory.Immunohistochemical method and image analysis techniques were used to determine the expression of AChE in Hippocampus.Results: Compared with normal group,in place navigation test,the mean escape latencies of the model group increased obviously,and in spatial probe test,the frequency of passing through the platform of the model group decreased obviously(P0.01).Compared with model group,the mean escape latencies of Tongluo Jiunao oral solution group(48、24、12mg·kg-1·d-1) decreased obviously(P0.05),and in spatial probe test,the frequency of passing through the platform of Tongluo Jiunao oral solution group(48、24、12mg·kg-1·d-1) increased obviously(P0.01).The expression of AChE had no difference between model group(P0.01) and normal group(P0.05).But compared with Tongluo Jiunao oral solution group,it had obviously significant difference.Conclusion: Tongluo Jiunao oral solution can reduce the disassociation of ACh by restraining the expression of AChE,and then improve the ability of learning and memory of AD rats.
【Fund】: 黑龙江省普通高等学校骨干教师创新能力资助计划项目(No.1055G065)
【CateGory Index】: R285.5
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