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《China Journal of Traditional Chinese Medicine and Pharmacy》 2007-08
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Effects of Mangiferin on Cell Cycle Status and Cyclin A,Cyclin B1 Expression of K562 Cells

PENG Zhi-gang1 LUO Jun1 LAI Yong-rong1 SONG Shan-jun2(1The First Affiliated Hospital,Guangxi Medical University,Nanning 530021;2Affiliated Union Hospital,Tongji Medical College,Huazhong University of Scienceand Technology,Wuhan 430027)  
Objective: To study the effect of mangiferin on cell cycle status and Cyclin A,Cyclin B1 expression in K562 cells,further to study the melocular mechanism for treating leukemia.Methods:The change of cell cycle status in K562 cells treated with mangiferin was performed by the flow cytometric;The expression of Cyclin AmRNA and Cyclin B1 mRNA was detected by semi-quantitative RT-PCR.Results: K562 cells in G2/M phase increased in a dose-dependent way after 24 hours mangiferin admininistration,indicating G2/M phase blockage;the expression of Cyclin A mRNA and CyclinB1mRNA enhanced in a dose-dependent way.Conclusion: Mangiferin blocked the cell cycle progression in G2/M phase,and it can significantly increase the the expression of Cyclin A and Cyclin B1at the mRNA level in K562 cells,G2/M phase blockage may be its one of the molecular mechanism for treating leukemia.
【Key Words】： Mangiferin K562 leukemic cells cell cycle Cyclins experimental study
【CateGory Index】： R285.5
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