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《China Journal of Traditional Chinese Medicine and Pharmacy》 2007-10
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Study on in situ intestinal absorption kinetics of icariin in rats

ZHAO Yan-hong1,2 JIA Xiao-bin1,2 CHEN Yan1 Ming Hu3(1Jiangsu Academy of Chinese Medicine Sciences,Jiangsu Engineering and Technology Research Center forModern Chinese Pharmaceutical Preparation,Nanjing 210028,China;2School of Pharmacy,Jiangsu University,Zhenjiang 212013,China;3University of Houston,U S A)  
To investigate the absorption kinetics characteristics of icariin for various intestinal segments.Methods: To establish the situ intestinal perfusion model and to study the absorption of icariin for various intestinal segments.Results: Icariin was metabolized quickly in the four intestinal segments.The permeability coefficient(P*eff) were(4.27±0.28),(5.25±0.17),(1.99±0.09),(0.80±0.03) at duodenum,jejunum,ileum,colon,respectively.Icariside can be detected in the four intestine segments in rats by HPLC.Conclusion: Icariin is metabolized into icariside,and then icariside can be absorbed.
【Key Words】： Icariin Absorption kinetics In situ intestine perfusion model Experimental study
【Fund】： 国家自然科学基金资助项目(No.30572372)
【CateGory Index】： R285.5
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