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《China Journal of Traditional Chinese Medicine and Pharmacy》 2008-03
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Signs evaluation in rat with spleen yang deficient syndrome from systems biology

YANG Xue,YANG Wen-si,WANG Yong,LI Wen-jing,ZHAO Shu-ying,TANG Bing-hua,LI Guo-zhang,ZHANG Bao-chun,CAI Da-yong(Beijing University of Chinese Medicine,Beijing 100029,China)  
Objective: To evaluate the signs in rats with spleen yang deficient syndrome from systems biology.Methods: At thermoneutrality(28℃) within 24 hours after being born(d1),rats had administrated intraperitoneally with various dosages of131I,fed with higher lipid feedingstuff and fasted 24 hours bidaily from d56,then administrated intragastrically with senna(equal to 10.0 g/kg) from d70,all the signs or symptoms associated with the spleen yang deficient syndrome had been observed within d63-d69 or d78-d84,included general state,weight loss,cold position,cold extremities,and less activity.The EC50 of131I had been analyzed with the software Prism-4 respectively to each of the signs or symptoms,the correlation between the signs or symptoms had also been analyzed with the excel for their cause-result connection.Results: The weight loss(P0.01),cold position(P0.05),cold extremities(P0.05) and less activity(P0.01),all signs or symptoms are positive correlative with the dosage of131I,i.e. the degree of hypothyroidism;and their EC50 to131I are 3220、 4315、12066 and 8863 nCi/g,respectively.The digestive overload had been exacerbating the clinic manifestations in the spleen yang deficient syndrome,except for that Senna alleviates the degree of cold position.The positive correlations are significant between weight loss and less activity(P0.05),cold extremities and less activity(P0.01),or cold position and cold extremities(P0.01).Conclusions The clinical manifestations in rats with spleen yang deficient syndrome belong to those in the yang deficient syndrome.It might be a phynomics for the ontology in traditional Chinese medicine.
【CateGory Index】: R256.4
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