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《China Journal of Traditional Chinese Medicine and Pharmacy》 2008-03
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Study on antioxidant activity of Clematis chinensis Osbeck polysaccharide

CHEN Yan1,SUN Yu-jun1,2,FANG Wei1(1The Key Lab of TCM Research and Development of Anhui Province,School of Life Science,Anhui University,Hefei 230039,China;2School of Life Science,Anhui Science and Technology College,Fengyang 233100,China)  
Objective: To study the antioxidant activity of Clematis chinensis Osbeck polysaccharide(CCP).Methods:① To assay the scavenging activity of CCP on hydroxyl radical and superoxide anion in vitro.② To analyze the effect of CCP on red blood cell autoxidation hemolysis induced by H2O2 by colorimetry.③ To study the effect of CCP on acute hepatic injury of the mice induced by carbon tetrachloride.Results: CCP could eliminate the hydroxyl free radical and the superoxide anion free radical,reduce red blood cell autoxidation hemolysis induced by H2O2,raise the activities of SOD and GSH-Px in hepatic injury mice's serum and liver apparently,reduce the content of MDA and liver index notably.Conclusion: CCP has the significantly action of anti oxidation activity in vitro and in vivo which relates to removing oxygen free radical.
【Fund】: 安徽省自然科学基金项目资助(No.070413143);; 安徽省高等学校自然科学研究重点项目资助(No.2005KJ020ZD)
【CateGory Index】: R285
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