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《China Journal of Traditional Chinese Medicine and Pharmacy》 2008-05
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Apoptosis induction effect of Pinellia extract fraction on cell lines of cervical cancer cultured in vitro

LI Gui-ling1,GUI Sui-qi1,CHEN Song-hua2,GE Xi-rui2,LIN Li-gen3,YE Yang3(1Obstetrics and Gynecology Hospital Affiliated to Fudan University Shanghai 200011,China;2Cell Resources Center,Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 200031,China;3Shanghai Institute of Materia Medica,Chinese Academy of Sciences Shanghai,201203,China)  
Objective: To investigate the apoptosis induction effect of Pinellia extract fraction(PE) on two cell lines of cervical cancer cultured in vitro,in order to fi nd a pure traditional Chinese reagent to treat cervical cancer effectively.Methods: PE was incubated in different concentrations with cervical cancer cell lines HeLa and CaSki.We tested the effects of PE on cell proliferation by MTT assay.The effects of PE on morphology,and cell cycle were studied by phase-contrast microscope and fiowcytometry(FCM).Results: PE could obviously inhibit the proliferation of HeLa and CaSki cells in a time and dose dependent manner.It could induce apoptosis of HeLa and CaSki.Conclusions: PE can suppress proliferation of cervical cancer cells and induce apoptosis.It may be a pure traditional Chinese reagent with non-side effects to prevent and treat cervical cancer effectively.
【Fund】: 上海市科委医学引导项目基金资助(No.074119613)
【CateGory Index】: R285;R737.33
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