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《China Journal of Traditional Chinese Medicine and Pharmacy》 2008-07
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Effect of QingreJiedu herbs in combination with Jiegeng decoction on expression of NF-κB p65 in ALI

ZHENG Feng-jie,LI Yu-hang,WANG Qing-guo,LI Li-na,JI Ye(Beijing University of Chinese Medicine,Beijing100029,China)  
Objective:To explore the e ect of QingreJiedu herbs in combination with Jiegeng decoction on expression of NF-κB p65 in ALI induced by LPS.Methods:Male Sprague-Dawley rats were randomly divided into normal group,model control group,QingreJiedu group,and the group of QingreJiedu herbs in combination with Jiegeng decoction.The model of ALI was made by injected with a single dose of LPS through vena femorali,the pathologic morphology,MPO activity and the expression of NF-κB p65 was observed.Result:Compared with normal group,infiltration.of PMNs,capillary congestion and swelling were found in model control group,and the content of MPO and expression of NF-κB p65 in the nuclear were significantly increased(P0.01or P0.05),the expression of NF-κB p65 in the cytolymph was decreased(P0.01).Both herb groups can decrease the content of MPO and expression of NF-κB p65 in the nuclear(P0.01 or P0.05),the group of QingreJiedu herbs in combination with Jiegeng decoction is better than QingreJiedu group.Conclusion:Jiegeng decoction can promote the QingreJiedu herbs to inhibit the transfer of NF-κB p65 from endochylema to nuclear,improve the e ect of detoxicating and anti-in ammation.
【Fund】: 国家自然科学基金项目(No.30672676)
【CateGory Index】: R285.5
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