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《China Journal of Traditional Chinese Medicine and Pharmacy》 2008-07
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Protective effect of Sini decoction on acute myocardial ischemia in rats

HE Jin,FANG Yan-wei,LI Yong-Min(Hebei North College,Zhangjiakou 075029,China)  
Objective:To study the protective e ect of Sini decoction on experimental myocardial ischemia in rats.Methods:The model of acute myocardial ischemia in rats was induced by subcutaneous injection of isoprenaline and sublingual venous injection of pituitrin.The changes of ECG,serum activity of creatine phosphokinase(CPK),lactate dehydrogenase(LDH),aspartate aminotransferase(AST),malondialdehyde(MDA) and superoxide dismutase(SOD)were measured.Results:Sini decoction signi cantly improved the extents of abnormal rising and lowering of ST segment(P0.05),decreased the activities of serum CPK,LDL,AST(P0.05),and MDA(P 0.01),increased the activity of SOD in rats of myocardial ischemia.Conclusion:Sini decoction has a protective e ect on experimental myocardial ischemia.
【Fund】: 河北省科技厅课题(No.07276483)
【CateGory Index】: R285.5
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