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《China Journal of Traditional Chinese Medicine and Pharmacy》 2009-05
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Optimizing preparation technology of Radix Angelicae Sinensis and Rhizome Chuanxiong in anti-anxiety Chinese drugs preparation though using EPM experiment

WU Li-kun, ZHANG Jian-jun, LI Wei, YUAN Cheng(Director:GAO Xue-min) (School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China)  
Objective:To optimize two preparation technologies (including decocting method and ambi-extracting method) of Radix Angelicae Sinensis and Rhizome Chuanxiong in anti-anxiety Chinese drugs preparation though using EPM experiment. Methods: KM healthy male mice were randomly divided into control group, diazepam group, anti-anxiety Chinese drugs(using decocting method of Radix Angelicae Sinensis and Rhizome Chuanxiong) high, middle and low doses groups, anti-anxiety Chinese drugs(using ambi-extracting method of Radix Angelicae Sinensis and Rhizome Chuanxiong) high, middle and low doses groups, mice in all groups but the control group were fed with corresponding drugs for 10 days, EPT pharmacodynamics experiments were carried out on the tenth day. Results: Open/Total time percent and Open/Total entries percent of mice in control group were lower than those in anti-anxiety Chinese drugs(using ambi-extracting method of Radix Angelicae Sinensis and Rhizome Chuanxiong) high, middle doses groups, which had obvious difference(P0.05).But no obvious difference was found among all anti-anxiety Chinese drugs(using decocting method of Radix Angelicae Sinensis and Rhizome Chuanxiong) doses groups. Conclusion: The anti-anxiety effect of anti-anxiety Chinese drugs using ambi-extracting method of Radix Angelicae Sinensis and Rhizome Chuanxiong surpasses that of using decocting method .
【CateGory Index】: TQ461
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