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《China Journal of Traditional Chinese Medicine and Pharmacy》 2009-07
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Investigation of the effects on small intestine motility of different ingredient groups in Banxiaxiexin recipe and Banxiaxiexin-allied recipes by using the BP neural network technique

YANG Xue-zhi1,GUO Zhou1,SI Yin-chu1,LI Hai-yan1,DU Hong1,ZHU Qing-wen1,SONG Xiao-li2,GAO Yan-qing3,LIU Xiao-ni4,NIU Xin1,SONG Yi-lun1(1Beijing University of Chinese Medicine,Beijing 100029,China;2 Shandong University of Traditional Chinese Medicine,Jinan 250014,China;3 Beijing You'an Hospital Affi liated to Capital Medical University,Beijing 100054,China;4 Mudanjiang Medical College,Mudanjiang 157011,China)  
Objective:To investigate the effects of the ingredient groups with different pharmacological features in Banxiaxiexin recipe and Banxiaxiexin-allied recipes on small intestine motility.Method:The homogeneous design method was adopted to classify the ingredients of Banxiaxiexin recipe and Banxiaxiexin-allied recipes.The effects of different ingredient matching and combinations on the impelling ratio of the small intestine were observed in the model mice in the normal control group,intestinal motility inhibition group and the intestinal motility hyperactivity group.The BP neural network technique was used to establish the nonlinear mapping model of the recipe ingredients and the criteria for their efficacy on the basis of the experimental data.Based on the nonlinear mapping model,the ratios of different ingredients in different ingredient groups were set up and the dose-effect relationships between different ingredient groups and the entire recipes were investigated.Result:In the Banxiaxiexin recipe and the two Banxiaxiexin-allied recipes,Rhizoma Pinelliae and Rhizoma Zingiberis in combination showed bidirectional regulative effect on intestinal motility in the mice in the intestinal motility inhibition group and the intestinal motility hyperactivity group,and Rhizoma Zingiberis alone had marked promotive effect on mouse intestinal motility while Rhizoma Pinelliae alone had no obvious such effect.Conclusion:In the experiments with the mice in different intestinal motility model groups,Rhizoma Pinelliae showed a pharmacodynamic action highly accordant with the one it showed in the entire Banxiaxiexin recipe,which suggests that Rhizoma Pinelliae might be the principal ingredient of the Banxiaxiexin recipe.As far as Rhizoma Zingiberis and Radix Glycyrrhizae are concerned,it was diffi cult to generalize their roles in the relevant recipes according to the results from the experiments on small intestine motility.
【Fund】: 国家自然科学基金资助项目(No.30672736);; 国家中西医结合基础重点学科211工程资助项目(No.2000-004)
【CateGory Index】: R289;R285.5
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