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《China Journal of Traditional Chinese Medicine and Pharmacy》 2010-05
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Influence in Shumai Capsule on Ang Ⅱinduced vascular smooth muscle dell proliferation and level of NO,SOD,MDA

DONG Jian-xun1,YU Sheng2,3,LU Guang-lin2,HAO Yu2,ZHANG Mei-ji2,ZHU Chao-jun1(1Beijing Hospital of Chinese Medicine,Capital Medical University,Beijing 100010,China;2Beijing University of Chinese Medicine,Bejing 100029,China;3The First Affi liated Hospital of Anhui Medical University,Hefei 230000,China)  
Objective:To observe the impact of the medicated serum of Shumai Capsule and its decomposing on vascular smooth muscle cells(VSMC) proliferation induced by angiotensinⅡ(AngⅡ) and level of NO,SOD,MDA in cell culture supernatant.Methods:Tissue explant method was used for cultivating vascular smooth muscle cells,serum pharmacology was used,AngⅡ10-7mol/L as a stimulating factor,medicared serum divided into Shumai Capsule group,Huoxue Huayu decomposing group(group 1) and Bupi Yishen decomposing group(group 2),MTT colorimetric was used to test OD values,biochemical detection kit was used to test NO,SOD,MDA levels.Results:The OD value of Shumai Capsule and group1 had significant difference from AngⅡ group and group2(P0.001);NO level of AngⅡgroup and group2 was lower than that of the control group,Shumai Capsule group and group1(P0.001);SOD level of AngⅡgroup,group2 was higher than that of the control group,Shumai Capsule group and group1(P0.001);MDA level of AngⅡ group,group2 was lower than that of the control group,Shumai Capsule group and group1(P0.001) too.Conclusion:Shumai Capsule group and group 1 had the effect of inhibiting cell proliferation.by promoting the secretion of NO and MDA,limiting the expression of SOD.The inhibitory effect of Shumai Capsule and group2 were the best.
【Fund】: 北京市中医药科技发展基金资助项目(No.JJ2005-13)~~
【CateGory Index】: R285.5
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