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《China Journal of Traditional Chinese Medicine and Pharmacy》 2010-07
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Effect of Yukuiqing on expression of connective tissue growth factor in human real mesangial cells incubated with AGEs

YANG Bing-quan1,SUN Zi-lin1,YU Jiang-yi2,GAO Feng1,LIU Su2 (1Department of Endocrinology,Southeast University Zhongda Hospital,Nanjing 210009,China; 2Department of Endocrinology,Jiangsu Provincal Hospital of TCM,Nanjing 210029,China)  
Objective:To investigate the effects of Yukuiqing (YKQ) on the expression of connective tissue growth factor (CTGF) in cultured human renal mesangial cells (HRMC) incubated with AGEs. Methods:The HRMCs were incubated with AGEs (200 μg/mL) and 1.25% YKQ which was prepared by Chinese herbal medicine serum pharmacological approach for 0,8,16,24,48 and 72h or different concentrations (0.313%,0.625% and 1.25%) of YKQ for 48h,respectively,which were incubated with DMEM and rat serum (RS) as the control. CTGF mRNA and protein were detected by reverse transcription polymerase chain reaction (RT-PCR) and Western Blotting respectively. Results:In Yukuiqing group,the expression of CTGF mRNA and protein decreased significantly compared with control groups (P0.05) and this decrease was in time dependent manner. The same result appeared in Yukuiqing group (0.313%,0.625%,1.25%) compared with control groups (P0.05). Conclusion:YKQ attenuated the expression of CTGF mRNA and protein in HRMCs incubated with AGEs. These results indicated that Yukuiqing might play the role of reno-protection via suppression of CTGF induced by AGEs.
【Fund】: 江苏省科技厅招标项目(No.BS2003056)~~
【CateGory Index】: R285
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