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《China Journal of Traditional Chinese Medicine and Pharmacy》 2010-12
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Experimental research on inhibition effects of Chinese herbal compound Songyou Yin on tumor growth and metastasis of residual hepatocellular carcinoma following palliative liver resection

HUANG Xiu-yan1,HUANG Zi-li2,TANG Zhao-you3,ZHENG Qi1,ZHOU Jian3,YE Sheng-long3 (1 The Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China;2The Central Hospital of Shanghai Xuhui District,Shanghai 200031,China;3Liver Cancer Institute,Fudan University,Shanghai 200032,China)  
Objective:To investigate the effects of Chinese herbal compound"Songyou Yin"on tumor growth and metastasis of residual hepatocellular carcinoma(HCC)following palliative liver resection in nude mice model.Methods: HCC models of palliative resection were established by orthotopic implantation of human HCC cell line MHCC97H xenografts.Thirty–six nude mice bearing residual HCC were randomized into control group and"Songyou Yin"group.Daily intragastric adminstration of"Songyou Yin"was given for 5 consecutive weeks 24 hours after palliative liver resection.Body weight was recorded weekly.Six mice in each group were sacrificed on the second day after treatment.Tumor volume,lung metastatic extent (grade),and the expression of IL-1βand proliferating cell nuclear antigen(PCNA)were examined.The remaining mice were used to observe life span.SAS 8.2 software was used for statistical analysis,and the significance was defined as P0.05.Results:The residual HCC tumor volume was(724.9±337.6)mm3 and(1205.2±581.3)mm3 in"Songyou Yin"group and control group respectively(P0.05),with tumor inhibition rate of 39.9%;the lung metastatic extent(grade)reduced significantly in "Songyou Yin"group(P0.05),body weight of mice in"Songyou Yin"group was heavier than that in control group(P0.001).IL-1βmRNA relative expression was significantly downregulated as comparison was made between two groups(P0.001),IL- 1βprotein level(Pg/mL)was(18.0±5.1)and(27.9±4.5)(P0.01),and the PCNA index(%)was(75.2±8.5)and(86.1±4.8)(P0.001) respectively at 5th week.The life span of mice in"Songyou Yin"group was significantly longer than that in the control,being(62.1±2.0)and(76.2±3.2d)(P0.05),the rate of prolong–life was 22.7%.Conclusion:Five weeks administration of Chinese herb"Songyou Yin"resulted in inhibition of tumor growth,delayed body weight loss,downregulated the expression of IL–1β and PCNA,and extended life span of nude mice bearing human HCC following palliative liver cancer resection,indicated its potential use in patients with advanced HCC.
【Fund】: 国家重点基础研究(973)项目(No.2004CB518708);; 上海交通大学附属第六人民医院课题(No.院-1131)~~
【CateGory Index】: R735.7
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