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《China Journal of Traditional Chinese Medicine and Pharmacy》 2010-12
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Study on the Therapeutic time window of Qingkailing’s neuroprotective effect in a mouse model of FCIR

CHENG Fa-feng,GUO Shao-ying,ZHONG Xiang-gen,LU Yi,WANG Qing-guo (School of Preclinical Medicine,Beijing University of TCM,Beijing,100029,China)  
Objective To study the protection and therapy time window of QKL injection on mice models of focal cerebral ischemia.Methods:Seventy Kunming mice were randomly and evenly divided into groups.Cerebral ischemia model of middle cerebral artery occlusion was established in mice using the suture method.Neurological deficit evaluations,such as Bederson,Clark scoring methods,were then carried out at 24 hours after MCAO and cerebral infarction volume were examined after the TTC staining.Results:The results showed that cerebral infarction volume reduced significantly after QKL injection administration at time 0、1、3、4、6h.Local cerebral injury recovered significantly,however there was no obvious difference between model group and other groups on general function injury or Bederson score except the 0h administration group.Conclusion:Qingkailing injection is a promising therapeutic strategy for cerebral ischemia and its therapeutic time window could last for 6 hours after the focal cerebral ischemia reperfusion,which would help in lessening the ischemic brain damage and improve neurological function.
【Fund】: 重大新药创制科技重大专项(No.2009ZX09102-136)~~
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Xu Ya1 Li Pengtao1 Xie Lijun2 Jia Xu1 Zhu Xiaolei3(1Beijing University of Traditional Chinese Medicine,Beijing 100029;2 The Third hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100029;3The World Federation of TCM Societies,Beijing 100101);Effects of Different Compositions of Qing Kai Ling Injection on Tumor Necrosis Factor in Brain of Rats with MCAO[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-07
2 ZHENG Yu, XIONG Li Ze, ZHU Zheng Hua, WANG Qiang, CHEN Shao Yang Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Study of therapeutic time window for Shenfu solution in transient focal cerebral ischemic injury in rats[J];Journal of The Fourth Military Medical University;2002-15
3 He Wei,Zhu Zunping,Liu Jianxin,Ye Heyang,Zeng Jin,Huang Xianhua,Lai Fei (Gannan Medical College,Ganzhou 341000);Study on Therapeutic Window of Opportunity for Panax notoginseng Saponins Following Focal Cerebral Ischemia/Reperfusion Injury in Rats[J];Journal of Chinese Medicinal Materials;2004-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XIE Ming-jian,XUE Wei-xin//The Traditional Chinese Medicine Hospital of Hezhou City,Hezhou 542800,China;Research situation on lesion of cerebral ischemia-transfusion treated with Traditional Chinese Medicine[J];Acta Medicinae Sinica;2005-05
2 HE Qian,LI Hua,ZHOU Xiao-qing,LIU Wang-hua,LIU Jian-xin,ZHANG Guo-min(TCM University of Hunan,Changsha,Hunan 410007,China);Effect of Danlong Xingnao tablet on expression of AI,Fas/FasL and TNF-α after cerebral ischemia-reperfusion in rats[J];Journal of Traditional Chinese Medicine University of Hunan;2009-02
3 LI Yang,YANG Bo,CHEN Shao-Yang,et al.Department of Anesthesiology,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032, China;Effects of shenfu injection pretreatment on the expression of HSP70 and HSP90 after cerebral ischemia-reperfusion injury in rats[J];The Journal of Clinical Anesthesiology;2010-01
4 JIANG Cui-lan1,CHEN Hong-yan2,HAN Ji-hong1,ZHANG Zhi-dong1,DU Hui-ru1(1.Department of Pharmaceutical Engineering,Hebei Chemical&Pharmaceutical Vocational Technology College,Shijiazhuang,Hebei,050026 P.R.China;2.Shjjiazhuang Yiling Pharmaceutical Inc.Shijiazhuang,Hebei,050035 P.R.China);Study on fingerprint of ginsenosides in Shenfu injection by HPLC[J];West China Journal of Pharmaceutical Sciences;2010-04
5 LI Da-zhen,YE Mao,XU Ying,SHI Yuan (Children Hospital Affiliated to Chongqing Medical University,Chongqing,P.R.China);S100 protein and NSE changes during cardiopulmonary bypass in infants and intervention effects of shenfu injection on them[J];Shandong Medical Journal;2007-11
6 ZHANG Yixuan MA Chuan'gen ZHAO Jingxia WANG Yong WANG Liping GUO Sulian The Research Institute of Anesthesia and Critical Care in Henan University,Department of Anesthesia,Huaihe Hospital,Henan University,Kaifeng 475000,China;Lidocaine combined with Shenfu injection alleviates systemic inflammatory response to cardiopulmonary bypass[J];Shanghai Medical Journal;2008-03
7 ZHU Xiaoling, XIONG Lize, CHEN Shaoyang, WANG Qiang, XU Ning, ZENG Yi Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Therapeutic time window of tetramethylpyrazine for focal cerebral ischemic/reperfusion injury in rats[J];Chinese Journal of Neurosurgical Disease Research;2006-04
8 Ying-hong TANG1,Shu-ping ZHANG2,Yan LIANG2,Chang-qing DENG2 1.Department of Pharmacology,College of Pharmacy,Hunan University of Traditional Chinese Medicine,Changsha,Hunan Province 410208,China 2.Laboratory of Pathophysiology,Hunan University of Traditional Chinese Medicine,Changsha,Hunan Province 410007,China;Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1β,its correlative factors and cysteinyl-aspartate specific protease after cerebral ischemia-reperfusion in rats[J];Journal of Chinese Integrative Medicine;2007-03
9 Song Li,Zhang Xue juan,Zhou Zan gong,Department of Anesthesiology,Affiliated Hospital of Medical College,Qingdao University,Qingdao 266003,Shandong Province,China;Protective effect of shenfu injection on gastrointestinal microcirculation in rabbits after myocardial ischemica-reperfusion injury[J];Chinese Journal of Clinical Rehabilitation;2005-11
10 HE Qian, ZHOU Xiao-qin, LI Hua, et al (Hunan University of TCM,Changsha 410007, China);Effect of Danlong Xingnao Tablet on the Expression of TNF-α and Apoptosis after Focal Cerebral Ischemia Reperfusion in Rat Hippocampus[J];Chinese Journal of Information on Traditional Chinese Medicine;2009-03
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Xi Jing, XIONG Li Ze, HU Wen Neng, ZHENG Yu, LU Zhi Hong Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Neuroprotection of preconditioning with oxygen inhalation against ischemic injury in transient middle cerebral artery occlusion rats[J];Journal of The Fourth Military Medical University;2002-15
2 ZHENG Yu, XIONG Li Ze, ZHU Zheng Hua, WANG Qiang, CHEN Shao Yang Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Study of therapeutic time window for Shenfu solution in transient focal cerebral ischemic injury in rats[J];Journal of The Fourth Military Medical University;2002-15
3 Zhu Xiaolei , Zhang Na , Li Pengtao , et al. (The Teaching and Research Section of Pathology, Beijing University of Traditional Chinese Medicine, Beijing 100029);Effects of Cholic Acid and Jasminoidin on the Levels of Cerebral TNF-α, IL-1 β and ICAM-1 in the Rats Undergone Cerebral Ischemia[J];Journal of Beijing University of Traditional Chinese Medicine;2004-06
4 HE Wei 1, CHEN Hui, ZENG Fan-DianInstitute of Clinical Pharmacology, Tongji Medical College of Huazhong Universit y of Science and Technology, Wuhan 430030, Hubei; 1 Department of Pharmacolog y, Jiangxi Gannan Medical College, Ganzhou 341000, Jiangxi;Protective effect of breviscapine on cerebral ischemia-reperfus ion injury and therapeutic window of opportunity[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2003-03
5 Xu Changqing, Xia Zuoli, Shi Yiju, et al. Department of Gerontology, Affiliated Hospital, Taishan Medical College, Shandong Province (271000).;The effect of PNS on the alterations of NO content and NOS activity in brain tissues following MCAO in rats.[J];Chinese Journal of Nervous and Mental Diseases;1997-02
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