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《China Journal of Traditional Chinese Medicine and Pharmacy》 2011-02
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Influence of diterpenoid curcumrinol C from ether extract of Radix Curcumae on human gastric cancer cell SGC-7901 in expression of Caspase-9,3,7,and PARP(89KD)

JIN Hai-feng1,LV Bin1,CHEN Zhe1,MA Zhong-jun2,WANG Lou-Lei3(1The First Affiliated Hospital,Zhejiang Chinese Medical University,Hangzhou 310006,China;2College of Pharmacy,Zhejiang University,Hangzhou310058,China;3The First Affiliated Hospital of Medical School of Zhejiang University,Hangzhou 310003,China)  
Objective: To investigate the effect on expression of Caspase-9,3,7,and PARP(89KD) of SGC-7901 by diterpenoid curcumrinol C from ether extract of Radix Curcumae.Methods: SGC-7901 cells were treated by curcumrinol C on four different concentrations(0,40,55,70μg/mL) and Western Blot hybridization was used for detecting expression of Caspase-9,3,7 and PARP(89KD) of SGC-7901 cells after treated by curcumrinol C.Results: Compared with the control group,curcumrinol C could increased the expression of Caspase-9,Caspase-3,Caspase-7 and PARP(89KD)(P0.05),which showed a dose-dependent.Conclusion: Curcumrinol C can induce tumor cells apoptosis by increasing the expression of Caspase-9,Caspase-3,Caspase-7 and PARP(89KD).
【CateGory Index】: R285;R735.2
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