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《China Journal of Traditional Chinese Medicine and Pharmacy》 2011-03
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Effects of Zhibai Dihuang Decoction on expression of IL-2, TNF-α in the testis of rats infected by ureaplasma urealyticum

LU Fang-guo,HE Qing-hu,ZHANG Bo,LIU Zhao-sheng,LI Ling(Hunan University of Chinese Medicine,Changsha 410208,China)  
Objective: In order to know the immune mechanism of Zhibai Dihuang Decoction(ZHBDHD) in treating male infertility by ureaplasma urealyticum(Uu),we performed the research for the effects of ZHBDHD on the expression of IL-2 TNF-α in the rats infected by Uu.Methods: Rats model was prepared by inoculating Uu in the bladder of rats.These rats were randomly divided into four groups: ZHBDHD group,minocycline group,model group and false operation group.The rats of model group and false operation group were taken NS by garage,twice a day for continuing 21 days;ZHBDHD group were taken ZHBDHD and minocycline group taken minocycline by garage as the other two groups.Stop water and food for 8 hours after the last garage,taken samples for determining the contents of IL-2,TNF-α in testis by immunohistochemistry and western bloting;determining mRNA of IL-2,TNF-αin testis with RT-PCR.Result: Compared with false operation group,the expressions of IL-2 in testis were obviously decreased after infected by Uu.However,TNF-α in testis were found obviously increasing after rats infected by Uu comparing with false operation rats;On the contrary,ZHBDHD could increase the expression of IL-2,inhibit the expression of TNF-α.The results were same when ZHBDHD group was compared with minocycline group.Conclusion: ZHBDHD can exert anti-inflammatory by effecting the expression of IL-2 and TNF-α in the rats infected by Uu.
【Fund】: 国家自然基金课题(No.30973759);; 湖南省自然基金课题(No.09JJ3054)~~
【CateGory Index】: R285.5
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