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《China Journal of Traditional Chinese Medicine and Pharmacy》 2011-07
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Effects of Huanglianjiedu-Decoction on blood pressure and inflammatory factors in spontaneous hypertension rats

ZHANG Zhi-wei,YUE Gui-hua,ZHANG Ai-zhen(Ruikang Hospital of Guangxi TCM University,Nanning 530011,China)  
Objective: To research the variety of the inflammatory factors and blood pressure of Spontaneous Hypertension Rats(SHR) with Huanglianjiedu-Decoction,and discuss the mechanism to cure hypertension.Method: 24 12-week-age male SHR were divided into three groups-Huanglianjiedu-Decoction group,the model group and Captopril group in random,treated for 6 weeks,tested the changes of the blood pressure pre and post the treatment separately,measured the density changes of the hs-CRP,6-K-PG,ET-1,vWF,Hcy,MCP-1 by ELLSA and NO by nitrous reductase chromatometry for those rats,and compared with 8 WKY rats in the same age for blank control.Results: The blood pressure of SHR increased progressively.The hs-CRP.ET-1.vWF.Hcy and MCP-1 increased,and 6-K-PG and NO decreased in the SHRs' plasma.Huanglianjiedu-decoction group could control the blood pressure of the SHR,decrease the content of the hs-CRP,Hcy,ET-1,vWF and MCP-1,and increase the content of the 6-K-PG and NO.Conclusion: Using Huanglianjiedu-decoction could improve the inflammatory response and control the hypertensive in the SHR.
【Fund】: 广西科学基金项目(No.桂科自0832177)~~
【CateGory Index】: R285.5
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