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《China Journal of Traditional Chinese Medicine and Pharmacy》 2011-09
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Protective effects of Jujube polysaccharide on liver injury in rats or mice induced by CCl_4

MIAO Ming-san,MIAO Yan-yan,WEI Rong-rui(Institute of Materia Medica,Henan College of TCM,Zhengzhou 450008,China)  
Objective: To explore the protective effects of Jujube polysaccharide on liver injury of rats or mice model induced by CCl4.Methods: Establish mice liver injury model by administration with 0.2% CCl4 and peanut oil admixture at the first,fourth and seventh day,and rats liver injury model by subcutaneous injection with 25% CCl4 and peanut oil admixture at the first,fifth days.Detecting the level of ALT in serum and observing liver pathological changes in those two animal models.Results: Mice and rats liver injury can be successfully induced by administration with different concentrations of CCl4 and peanut oil admixture.Large and low-dose of Jujuba polysaccharide can significantly lower the levels of ALT in serum and simultaneously reduce pathological changes of liver tissue in those two models.Conclusion: Jujube polysaccharide has good protective effects on liver injury in rats or mice induced by CCl4.
【Fund】: 河南省高等学校创新人才培养工程(No.2004-23)~~
【CateGory Index】: R285.5
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