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Effects of Yinaokang Capsule on NO,VEGF,PDGF-BB content in serum of rats with atherosclerotic acute cerebral ischemia

ZHU Lei1,ZHANG Yan-hong2,SHI Guang3,CHEN Jie4,LUO En-li5,HUANG Yan5(1Guangzhou University of Chinese Medicine,Guangzhou 510405,China;2First People's Hospital of Guangzhou City,Guangzhou 510180,China;3First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;4Foshan City Hospital of Traditional Chinese Medicine,Foshan 528000,China;5Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China)  
Objective:By observing the effects of Yinaokang Capsule on NO,VEGF and PDGF-BB content in serum of atherosclerotic acute cerebral ischemic SD rats,the possible mechanism of the capsule for preventing ischemic stroke is investigated.Methods:SD male rats weighted(180±20)g were randomly divided into 6 groups:A,B,C,D,E,F(Respectively for the normal control group,the Yinaokang Capsule prevention group,the AS model group,the AS + ACI model group,the Yinaokang Capsule treatment group and the Lipitor treatment group).AS model is replicated by intraperitoneal injection of VD3 + high fat diet,and ACI model is replicated by the injection of ET-1 near the MCA.Rats of group B were treated with Yinaokang gastric perfusion while the modeling,the other rats were given saline,Yinaokang and Lipitor by gavage 1 week after successful modeling.The levels of NO,VEGF,and PDGF-BB in serum were measured before and after treatment.Results:NO content in serum of group B and group F was significantly higher than that of group D(P0.01,P0.05).Compared with group D,VEGF and PDGF-BB levels in the serum of Group B,E,F were significantly decreased(P0.01,P0.05).Conclusion:By increasing serum NO content and decreasing the content of VEGF,PDGF-BB,Yinaokang Capsule plays the role of prevention and treatment in rats of atherosclerotic acute ischemic stroke.
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