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《China Journal of Traditional Chinese Medicine and Pharmacy》 2012-08
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Effects of Yinaokang Capsule on NO,VEGF,PDGF-BB content in serum of rats with atherosclerotic acute cerebral ischemia

ZHU Lei1,ZHANG Yan-hong2,SHI Guang3,CHEN Jie4,LUO En-li5,HUANG Yan5(1Guangzhou University of Chinese Medicine,Guangzhou 510405,China;2First People's Hospital of Guangzhou City,Guangzhou 510180,China;3First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;4Foshan City Hospital of Traditional Chinese Medicine,Foshan 528000,China;5Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China)  
Objective:By observing the effects of Yinaokang Capsule on NO,VEGF and PDGF-BB content in serum of atherosclerotic acute cerebral ischemic SD rats,the possible mechanism of the capsule for preventing ischemic stroke is investigated.Methods:SD male rats weighted(180±20)g were randomly divided into 6 groups:A,B,C,D,E,F(Respectively for the normal control group,the Yinaokang Capsule prevention group,the AS model group,the AS + ACI model group,the Yinaokang Capsule treatment group and the Lipitor treatment group).AS model is replicated by intraperitoneal injection of VD3 + high fat diet,and ACI model is replicated by the injection of ET-1 near the MCA.Rats of group B were treated with Yinaokang gastric perfusion while the modeling,the other rats were given saline,Yinaokang and Lipitor by gavage 1 week after successful modeling.The levels of NO,VEGF,and PDGF-BB in serum were measured before and after treatment.Results:NO content in serum of group B and group F was significantly higher than that of group D(P0.01,P0.05).Compared with group D,VEGF and PDGF-BB levels in the serum of Group B,E,F were significantly decreased(P0.01,P0.05).Conclusion:By increasing serum NO content and decreasing the content of VEGF,PDGF-BB,Yinaokang Capsule plays the role of prevention and treatment in rats of atherosclerotic acute ischemic stroke.
【Fund】: 国家科技部“十五”攻关课题(No.2004BA721A02)~~
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 1 Hits
1 LI Yue 1,2,SUN Jing-bo 2,HUANG Yan 2(1.Second Clinical Medicine College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;2.Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,China);Protective Effects of Yinaokang Capsule on Blood-brain Barrier and Influence on Expression of ZO-1 Protein after Thrombolysis Therapy in Cerebral Ischemia Rats[J];Chinese Journal of Experimental Traditional Medical Formulae;2013-11
【Citations】
Chinese Journal Full-text Database 4 Hits
1 YANG Peng Yuan,RUI Yao Cheng *,JIAO Ya Bin (Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China);Establishment of experimental atherosclerosis model in rats[J];Academic Journal of Second Military Medical University;2003-07
2 GU Guo-jun,HUANG Zhen-xing,TAO Kai-zhong,LIU Yun,TAO Heng-yi,PENG Zhao-yun,SUN Xue-jun~*(Department of Diving Medicine,Faculty of Navy Medicine, Second Military Medical University,Shanghai 200433,China);Effect of hyperbaric oxygen on an endothelin-1-induced focal cerebral ischemic model in rats[J];Academic Journal of Second Military Medical University;2006-10
3 HAN Ying, XIE Liang-di, XU Chang-sheng, WANG Hua-jun (Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China);Effect of fluvastatin on migration of vascular smooth muscle cells from rats[J];Chinese Journal of Pathophysiology;2005-11
4 CAI Ye-feng,FU Yu,GUO Jian-wen,YOU Jin-song,WANG Li-xin,LIANG Wei-xiong,HUANG Yan,HUANG Pei-xin(The First Department of Neurology,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,China);Randomized Multicenter Control Clinical Study on Acute IschemicStroke Treatment with Traditional Chinese Medicine[J];Journal of Chinese Medicinal Materials;2007-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Hao Yan1,Yang Qiaolan1,Yu Yi1,Han Yuzhen1,Chen Ming2(1.Department of Nephrology,Affiliated Hospital,Luzhou Medical College,Luzhou,Sichuan 646000,China; 2.Department of Nephrology,Affiliated Hospital,Chengdu Unversity of TCM,Chengdu,Sichuan 610072,China);Establishment of a rat model of atherosclerosis combined with renal artery stenosis[J];Chongqing Medicine;2012-06
2 JIAO Ya-bin,RUI Yao-cheng *,YANG Peng-yuan,LI Tie-jun,QIU Yan(Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China);Expression of IL-1β,TNFα,IL-10 and IL-10R in aorta of atherosclerotic rats and effects of Ginkgo biloba extract on their expression[J];Academic Journal of Second Military Medical University;2005-02
3 JIA Ai-ming,ZHANG Hong(Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China);Mechanism of action of Qishenjiangzhiyin(QSJZY) on experimental atherosclerosis rats[J];Journal of Dalian Medical University;2007-01
4 YU Hui-zhen1,2,XIE Liang-di1,ZHU Peng-li2,XU Chang-sheng1 1Fujian Provincial Institute of Hypertension,First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China;2Second Medical Department,Provincial Clinical College,Fujian Medical University,Fuzhou 350001,China;Effects of human tissue kallikrein gene transfer on the migration of vascular smooth muscule cells[J];Journal of Southern Medical University;2010-04
5 HUANG Zhen-yu~1, YANG Peng-yuan~2, YU Yan-ling~1, FAN Hui-zhi~1, RUI Yao-cheng~2, YANG Peng-yuan~1 (1. Chemistry Department, Fudan University, Shanghai 200433, China;2. Pharmaceutical College, Secondary Military Medical University, Shanghai 200433, China);Protein Expressions of Atherosclerotic Rat Myocardium by Two-dimensional Gel Electrophoresis[J];Journal of Fudan University;2003-06
6 LIN Wei,CAO Zhi-yun,CHEN Xu-zheng,et al(Fujian Academy of Integrative Medicine,FUTCM,Fuzhou,Fujian 350108,China);Effect of Xuefu Zhuyu Decoction on Migration of Vascular Smooth Muscle Cells in Rats[J];Journal of Fujian University of Traditional Chinese Medicine;2009-05
7 Xu Xuejing,Du Guangsheng,Hong Lifeng,He Li,Ma Yexin(Department of Cardiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China);NF-κB mediates upregulation of inducible nitric oxide synthase expression in rat aortas by asymmetric dimethylarginine[J];Chinese Journal of Histochemistry and Cytochemistry;2011-01
8 Hu Sigan,Chai Damin1,Qiao Chenchen,Shao Shan,Wu Shili,Gao Dasheng,Wang Hongju(Department of Cardiovasology,First Affiliated Hospital,Bengbu Medical College,Anhui 233004;1Department of Pathology,Bengbu Medical College,Anhui 233030,China);Effect of simvastatin on apoptosis related genes fas and fasl protein expression[J];Chinese Journal of Histochemistry and Cytochemistry;2011-02
9 Lan Pengfei,Wang Jingli﹙Gansu College of Traditional Chinese Medicine,Lanzhou 730000,China﹚;Influence of Xintongning Adhesive Plaster on the level of blood-lipid and TNF-α,IL-6 in serum of rats with myocardial ischemia[J];Journal of Gansu College of Traditional Chinese Medicine;2009-06
10 WANG Yi-yong☆,JIA Shao-bin,LIU Jing,HOU Jian-jun,ZHANG Zheng-jun.☆Center of Cardiology,General Hospital,Ningxia Medical University,Yinchuan 750004,China.;Methylation and mRNA expression of Bcl-2 in hyperlipidemia Wistar rats[J];Guangdong Medical Journal;2012-19
China Proceedings of conference Full-text Database 1 Hits
1 LAN Xiao-hong,ZHOU Yong-gang,LI Xiang,XU Rui PLA 81 Hospital,Nanjing 210002,China;Evaluation of Experimental Model of Atherosclerosis in Rats[A];[C];2010
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 LAO Yi,XIU Jian-cheng,XIE Chang-lian,CHEN Xiang-hui,WU Jue-fei,BIN Jian-ping,LIU Yi-li Department of Cardiology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Ultrasound-mediated microbubble destruction increases capillary permeability in rat skeletal muscles[J];Journal of Southern Medical University;2008-04
2 LIU Maocai, HUANG Yan, DU Baoxin, ZHANG Liang, ZHU Ming, LIANG Weixiong, HUANG Peixin, WEN Zehuai, OU Aihua (The Second Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510120,China);Traditional Medicine Combined with Western Medicine for Hypertensive Middle-and Large-Amount Cerebral Hemorrhage:A Report of 201 Cases[J];Journal of Guangzhou University of Traditional Chinese Medicine;2001-01
3 LI Gui-zhu1,CHEN Qian-fen2,MA Lin2 (1Dept of Pathology,Second People's Hospital of Hefei,Hefei 230011,China;2Dept of Pathophysiology,Bengbu Medical College);Protective effect of tetramethylpyrazine and ischemic preconditioning against cerebral ischemic reperfusion injury in rats[J];Journal of Shanxi Medical University;2010-02
4 QIN Xiu-de1,HUANG Yan2,ZHU Lei1,ZHOU Xi-yan3,CHEN Jie3(1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Guangdong Province Hospital of Traditional Chinese Medicine,Guangzhou 510120,China;3.Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China);Yinaokang Effect on AS Based AIS SD Mices' Brain VEGF Expression and Brain Pathological Change[J];Chinese Journal of Experimental Traditional Medical Formulae;2010-16
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Lao Ying-rong1, Guo Xin-feng1,2, Lai Shi-long1,2, Liang Wei-xiong1,2, Wen Ze-huai1,2, Wang Qi1,2, Huang Pei-xin3, Huang Yan3, 1Research Institute of Applied Clinical Epidemiology, 3Department of Neurology, Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine(Guangzhou Provincial Hospital of Traditional Chinese Medicine), Guangzhou 510120, Guangdong Province, China; 2Center for DME, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong Province, China;Comparison of outcome assessments of stroke convalescence by using multiple scales based on different dimensions[J];Chinese Journal of Clinical Rehabilitation;2005-29
2 MEI He Shan ,SU Su Wen, WANG Yong Li,LI Hai Fang (Dept of Pharmacology,Hebei Medical University,Shijiazhuang 050017);The focal cerebral ischemia and reperfusion model induced by Endothelin-1 in rat[J];Chinese Pharmacological Bulletin;2004-01
3 YANG Peng yuan 1, RUI Yao cheng 1, Zhang Li 1, LI Tie jun 1, QIU Yan 1, WANG Jie song 1, ZHANG Wei dong 2 (1. Department of Pharmacology, 2. Department of Medical Chemistry of Natural Products, Second Military Medical University, Shanghai;EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN U937 FOAM CELLS AND THE INHIBITORY EFFECT OF DRUGS[J];Acta Pharmaceutica Sinica;2002-02
4 YANG Peng-Yuan, RUI Yao-Cheng, LI Kai (Department of Pharmacology, School of Pharmacy; Department of Thoracic Cardiac Surgery, Changhai Hospital, The Second Medical Military University, Shanghai 200433, China); HUANG Xing-Hua, JIANG Jian-Ming, YU Long (Institute of Genetics, Fudan University, Shanghai 200433, China);Expression of intercellular adhesion molecule-1 in U937 foam cells and inhibitory effect of imperatorin[J];中国药理学报(英文版);2002-04
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