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《China Journal of Traditional Chinese Medicine and Pharmacy》 2013-09
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Experimental study on effects of Xuzao Gengping Powder on the vascular remodeling in climacteric hypertension rats

ZHOU Bin,LIN Xue,MA Li,LI Hong-xia,WANG Jing (Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Urumqi 830000,China)  
Objective:To explore reverse vascular remodeling effect and possible mechanism in climacteric hypertension rats with Xuzao Gengping Powder.Methods:Climacteric hypertension model rats were established and randomly divided into traditional Chinese medicine group,western medicine group,climacteric hypertension group,fake operation and SHR groups. WKY group was set as a normal control group.The traditional Chinese medicine group was drenched with Xuzao Gengping powder,and the western medicine group with Valsartan Capsule.The other groups were drenched with distilled water.Results: The vascular remodeling of climacteric hypertension rats was more serious than SHR rats'.There was no difference between climacteric hypertension traditional Chinese medicine and climacteric hypertension western medicine,and both of them were smaller than WKY,MT、MT/LD decreased(P0.05).The traditional Chinese medicine group and western medicine group were larger than WKY(P0.05).Compared with the climacteric hypertension,fake operation and SHR groups,MMP-9 and TIMP- 1 levels in serum of traditional Chinese medicine group and western medicine group decreased(P0.05).Conclusion:Xuzao Gengping Powder can significantly reduce vascular tissue damage caused by high blood pressure.By reducing MMP-9 and TIMP- 1 in serum and restoring balance of MMP-9/TIMP-1 might be the effective mechanism for preventing and reversing vascular remodeling in climacteric hypertension rats.
【Fund】: 国家自然科学基金项目(No.81160430)~~
【CateGory Index】: R271.9
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