Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《China Journal of Traditional Chinese Medicine and Pharmacy》 2013-10
Add to Favorite Get Latest Update

Study on the antihypertensive effect and related substances of Cydonia oblonga Mill. (COM) leaf extracts on renal hypertension rats

ZHOU Wen-ting;Ablat Abliz;WANG Xue-fei;Qimangul Aji;TIAN Shu-ge;SUN Xiao-wei;Anwar Umar;Xinjiang Medical University;  
Objective: To study the antihypertensive efect and related substances Cydonia oblonga Mill.(COM) leaf extracts,such as angiotensin-Ⅱ(AngⅡ),renin activity(RA),apelin-12,endothelin(ET) and nitric oxide(NO).Methods: Twokidney,one-clip(2K1C) model rats were operated and divided randomly into six groups: sham group,model group,captopril group,COM leaf extracts low,medium and high dose groups,10 rats in each group.The drugs were administered for eight weeks.Systolic blood pressure(SBP) and diastolic blood pressure(DBP) were measured before and every 2 weeks after administration.After the last administration,all rats were sacriiced under deep anesthesia,and blood and kidney samples were collected to detect the level of AngⅡ,RA,apelin-12,ET and NO.Results: After treatment for eight weeks,COM leaf extracts signiicantly declined the pressure of RHR(P0.05),which had no signiicant diference in COM high dose group compared with captopril group;In COM leaf extracts groups,the levels of AngⅡ,apelin-12,RA and ET were declined,while the level of NO was increased.Conclusion: The antihypertensive activity of COM leaf extracts may be related to action on the renin-angiotensin system and balance of the vaso-excitor materials and vasodilator substances.
【Fund】: 新疆维吾尔自治区科技计划项目(No.201033126)~~
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 LI Tiao1,CHEN Li-guo2,LI Quan3,ZHOU Yong-hong2,TANG Hai-lan2,CHENG Shao-bing2(1Zhuhai People's Hospital,Zhuhai 519000,China;2Jinan University,Guangzhou 510632,China;3Qinhuangdao Hospital of TCM,Qinhuangdao 066000,China);The protective effects of Tetramethylpyrazine(TMP) combined with Astragalus Polysaccharides(APS) on vascular endothelial cells(VECs)[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-11
2 GULISIMAYI Aibaidula,GULIMUER Maimaiti,AIKEPAER Simayi,ABUDULA Abbas(College of Life Science and Technology,Xinjiang University,Urumqi 830046,China);Antibacterial Effect of Flavone Extract from Xinjiang Cydonia oblonga Mill[J];Food Science;2009-03
3 YAN Wen,Hannisa·ROZI,Patigul·MAHMUT* (College of Life Sciences and Technology, Xinjiang University, Urumqi 830046, China);Antimicrobial Activity of Crude Alkaloid Extract from Cydonia oblonga Mill Fruit[J];Food Science;2009-23
4 Guzilinuer·Yimamu,Wuliya·Yimin,Yibadeiti·Tuheti,et al(Department of Pharmacology,Xinjiang Medical University,Urumqi 830011,China);Antihypertensive effects of Ocimum Basilicum L (OBL) on renal hypertensive rats[J];Journal of Xinjiang Medical University;2009-03
5 Ablat Abliz1,Wuliya Yimin1,ZHOU Wen-ting1,Guzelnur Imam2,Minawar Happar1, Ibadet Tohti1,Anwar Umar1(1Department of Pharmacology,2Department of Traditional Uyghur Medicine, Xinjiang Medical University,Urumqi 830011,China);Experimental study on antihypertensive effect of Cydonia oblonga Mill[J];Journal of Xinjiang Medical University;2012-04
Chinese Journal Full-text Database 10 Hits
1 XU Ling-fei,LIU Ya-jie,LI Hui,JIA Dong-feng(College of Horticulture,Northwest Agricultural and Forestry University,Yangling,Shaanxi 712100);Hardwood Cutting Propagation of Yunnan Quince as a Dwarf Rootstock of Pear[J];Northern Horticulture;2011-17
2 ZHANG Yu-yan,LI Jian,WAN Hai-tong,LAI Li-li,YANG Jie-hong,ZHOU Hui-fen,WANG Yu (Zhejiang University of Chinese Medicine,Hangzhou 310053,China);Study of protective effects of compatibility of astragaloside A with ligustrazine on cerebral ischemic reperfusion injury[J];China Journal of Traditional Chinese Medicine and Pharmacy;2013-09
3 XUE Jin;WANG Qing-guo;LI Yi-fei;SUN Ye;HU Li-na;ZHAO Yan;QU Hui-hua;WANG Xue-qian;Beijing University of Chinese Medicine;;Effects of drug serum of Sancao Jiangya Decoction different components on cell viability of H_2O_2-induced oxidative damage model in human umbilical vein endothelial cell[J];China Journal of Traditional Chinese Medicine and Pharmacy;2013-10
4 XU Xiao-hong;WANG Li;ZHANG Ning-kun;ZHENG Nan;GAO Liao-ru;ZHU Zhi-ming;Affiliated Clinical Faculty of Navy General Hospital,Anhui Medical University;Department of Cardiology,Navy General Hospital;;Influence of apelin-13 on 5-azacytidine inducing differentiation of umbilical cord mesenchymal stem cells to cardiomyocytes[J];Medical Journal of Chinese People's Liberation Army;2013-10
5 ZHENG Nan;ZHANG Ning-kun;GAO Lian-ru;XU Xiao-hong;WANG Li;ZHU Zhi-ming;Heart Center of Naval Clinical Medical College,Second Military Medical University;Department of Cardiology,Navy General Hospital;;Effect of exogenous apelin-13 on cardiac stem cell mobilization in rats with myocardial infarction[J];Medical Journal of Chinese People's Liberation Army;2013-10
6 PAN Ju-ying;PENG Ju-lan;LIU Yuan-yuan;The Second Department of Obstetrics, People's Hospital of Longhua New District of Shenzhen;;Clinical significance of serum Apelin changes in patients with hypertensive disorder in pregnancy[J];Hainan Medical Journal;2013-20
7 WANG Li;TANG Chu-zhong;ZHU Zhi-ming;Clinical College of Navy Medicine, Second Military Medical University;Department of Cardiology, Navy General Hospital;;Relationship between regulation of signaling pathways in heart development and congenital heart diseases[J];Medical Journal of Chinese People's Liberation Army;2013-11
8 ZHANG Zhong-xian,WEI Xiu-juan.Dept.of Cardiology,Traditional Chinese Medical Hospital of Dongchangfu,Liaocheng,Shandong 252000,China;The influence from Ligustrazine on serum NT-proBNP level of patients with chronic heart failure[J];Chinese Journal of Clinical Rational Drug Use;2012-17
9 (1 Guangzhou University of Chinese Medicine,Guangzhou 510405,China;2 Zhongshan Hospital of Traditional Chinese Medicine,Zhongshan 5284000,China;3 No.1 Hospital Affiliated of GuiYang College of Traditional Chinese Medicine,Guiyang 550001,China;4 GuiYang College of Traditional Chinese Medicine,Guiyang 550002,China);Study on the Intervention Effect of Bushenyixin Decoction on the Vascular Endothelial Dysfunction in Spontaneously Hypertensive Rats[J];World Chinese Medicine;2013-08
10 Yang Zhijie 1,Li Xiuli 2(1 Shandong Liming Polytechnic Vocational College,Jinan 250036,China;2 Shandong University of Traditional Chinese Medicine,Jinan 250355,China);Research Progress of Ocimum Basilicum L[J];World Chinese Medicine;2013-08
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LI Fei (Postgraduate student of Grade 2003,Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038, China);Study on the Compound Model of Hypertension and Hyperlipemia in Rats[J];Journal of Anhui Traditional Chinese Medical College;2005-03
2 WANG Xiuqing,GAO Zhen,GUO Hong,et al.Lab of Military Pathology,Bethune military Medical College,Shijiazhuang 050081,China;Creation of Chronic Stress Hypertension Animal Model[J];Journal of Bethune Military Medical College;2003-04
3 YU Li-li, LI Li, CHEN Ming, WU Guo-ping, HU Chun-xiou, ZHU Zhi-ming (Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Cold-stress stimulates pregnancy-induced hypertension syndrome in pregnant rats[J];Acta Academiae Medicine Militaris Tertiae;2001-04
4 CHEN Yue-yuan~1, LI Dian-peng~(1*), GAO Jiang-lin~2( 1.Guangxi Institute of Botany, Guangxi Zhuangzu Autonomous Region and Academia Sinica, Guilin 541006, China; 2.Guilin Sanjin Pharmaceutical Co.LTD, Guilin 541002, China );Study on extraction and determination of total alkaloid of cortex Phellodendri[J];Guihaia;2003-06
5 PENG Xiao-dong, WU Keng, LI Qian, CHEN Mei (Department of Emergency, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China);The relation between pulse pressure and endothelial function of artery in the elderly patients with essential hypertension[J];Hainan Medical Journal;2006-10
6 YANG Ning, HU Libin, ZHANG Zhongzhong,et al. Chinese Academy of Medical Sciences Beijing Union Medical College Department of Radiology, Beijing Union Medical College Hospital, Beijing 100730, China;Establishment of unilateral renovascular hypertension in dogs and mark monitoring[J];Journal of Interventional Radiology;2002-02
7 ZHANG Bixia,HU Zhaoyu,ZHANG Tong,YE Ping,Military Hospital No.44,Guiyang,Guizhou Province 550009;Discussion of the Relationship between Vascular Endothelium Function and OX-LDL Change in Senile Patients with Hypertension[J];Journal of Military Surgeon in Southwest China;2007-05
8 YU Xiang-dong 1, ZHOU Wen-quan 2, CUI Ling 2, JU Da-hong 3, WANG Shuo-ren 4, QIN La-mei 4, TENG Jing-ru 3, PAN Jing-hua 3 (1. Beijing Institute of Geriatrics Xuanwu Hospital, Capital Univ.of Medical Science, Beijing 100053, China; 2.Xiyuan Hospital, China Academy of TCM, Beijing 100091, China; 3.Fundamental Theory of TCM Institute, Beijing 100007, China; 4.Center Lab., Dongzhimen Hospital, Beijing 100007, China);EFFECTS OF LUOHUO CAPSULE ON LEVELS OF ADM AND TFPI IN PLASMA OF HYPERTENSION RATS[J];Journal of Shandong University of Traditional Chinese Medicine;2004-01
9 ZHANG Xiao-hua, LI Shan-quan, SHEN Jia-ling, et al ( Department of Neurosurgery, Renji Hospital, SSMU, Shanghai 200001, China);Establishment of Canine Model for Primary Hypertension[J];Acta Universitatis Medicinalis Secondae Shanghai;2003-05
10 Ma Chengbin 1 Zhuang Yiliang 1 Yang Youming 2 Zhou Guangxing 2 Lü Yuan 3 Li Ai lu 4 ( 1Obstetrics and Gynecology Hospital, 2Department of Laboratory Animal Science, 3Hua Shan Hospital,Shanghai Medical University,Shanghai 200011;;Duplication of a New Animal Model for Pregnancyinduced Hypertension[J];XHANGHAI LABORATORY ANIMAL SCIENCE;1997-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved