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《China Journal of Traditional Chinese Medicine and Pharmacy》 2013-10
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Study on the antihypertensive effect and related substances of Cydonia oblonga Mill. (COM) leaf extracts on renal hypertension rats

ZHOU Wen-ting;Ablat Abliz;WANG Xue-fei;Qimangul Aji;TIAN Shu-ge;SUN Xiao-wei;Anwar Umar;Xinjiang Medical University;  
Objective: To study the antihypertensive efect and related substances Cydonia oblonga Mill.(COM) leaf extracts,such as angiotensin-Ⅱ(AngⅡ),renin activity(RA),apelin-12,endothelin(ET) and nitric oxide(NO).Methods: Twokidney,one-clip(2K1C) model rats were operated and divided randomly into six groups: sham group,model group,captopril group,COM leaf extracts low,medium and high dose groups,10 rats in each group.The drugs were administered for eight weeks.Systolic blood pressure(SBP) and diastolic blood pressure(DBP) were measured before and every 2 weeks after administration.After the last administration,all rats were sacriiced under deep anesthesia,and blood and kidney samples were collected to detect the level of AngⅡ,RA,apelin-12,ET and NO.Results: After treatment for eight weeks,COM leaf extracts signiicantly declined the pressure of RHR(P0.05),which had no signiicant diference in COM high dose group compared with captopril group;In COM leaf extracts groups,the levels of AngⅡ,apelin-12,RA and ET were declined,while the level of NO was increased.Conclusion: The antihypertensive activity of COM leaf extracts may be related to action on the renin-angiotensin system and balance of the vaso-excitor materials and vasodilator substances.
【Fund】: 新疆维吾尔自治区科技计划项目(No.201033126)~~
【CateGory Index】: R285.5
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