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《China Journal of Traditional Chinese Medicine and Pharmacy》 2014-05
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Study of Xinfeng Capsule on the pulmonary function based on BTLA,Tregs and surface markers FoxP3 in the rats with adjuvant arthritis

WAN Lei;LIU Jian;The First Affiliated Hospital of Anhui University of Chinese Medicine;  
Objective: To observe the impact of Xinfeng Capsule on pulmonary function, B and T lymphocytes attenuator(BTLA), regulatory T cells(Treg) and FoxP3 in the rat model of adjuvant arthritis. Methods: 60 rats were randomly divided into normal group, model group, tripterygium group and Xinfeng Capsule group. Except for the normal group, the adjuvant was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw. On the 19th day after modeling, the normal and model groups were given physiological saline, while the tripterygium group and Xinfeng Capsule groups were given tripterygium glycosides tablet(10mg/kg) and Xinfeng Capsule(2.4g/kg), once daily for 30 days, respectively. Changes in paw swelling, the arthritis index, levels of BTLA, Treg in peripheral blood were observed by l ow cytometry, the expressions of BTLA, FoxP3 in synovial and lung tissue were detected by Western blot. Results: Compared with the normal group, the paw swelling, arthritis index increased, and pulmonary function parameter, BTLA, Treg in peripheral blood, and BTLA, FoxP3 in synovial and lung tissue decreased significantly in the model group(P0.05, P0.01). The paw swelling, arthritis index were lower, and pulmonary function parameter, Treg, BTLA, FoxP3 were higher in Xinfeng Capsule group than those in the model group(P0.05, P0.01). Xinfeng capsule group was also much better than tripterygium group in improving pulmonary function, Treg, BTLA, FoxP3(P0.05). Conclusion: Xinfeng Capsule can improve pulmonary function by upregulating the levels of, BTLA, Tregs and FoxP3, and reducing inl ammatory mediators.
【Fund】: 国家自然科学基金(No.81173211);; 国家科技支撑计划课题(No.2012BA126B02);; 国家中医药重点学科中医痹病学建设项目(No.国中医药发[2009]30号)~~
【CateGory Index】: R285.5
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