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《Journal of Peking University(Health Sciences)》 1981-04
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RESEARCH ON PATHOGENETIC MECHANISM AND EXPERIMENTAL THERAPY OF SHOCK——EFFECT OF INTESTINAL ISCHEMIA ON THE PATHOGENESIS OF SHOCK

Tang Chao-shu Department of Pathophysiology, Beijing Medical College  
Superior mesenteric artery occlusion (SMAO)shock was reproduced in rabbits under local anesthesia as shock model. It Was shown that primary intestinal ischemic damage itself could lead to severe irreversible shock. Further experiments demonstrated that antegrade intraarterial infusion of H_2O_2 IE, or Ⅳ medication of Anisodamine had improved intestinal tissue ischemia, and prevented the irreversibility of the shock process. These results suggested that small intestine is probably the "key organ" in the occurrence of irreversible shock.654-2 given intraenterically decreased the release of lysozymal enzyme (acid phosphatase) from the ischemic intestine, which tissue was obviously protected, and shock could be relieved, while α-adrenergic blocking agent phenoxybenzamine showed no antishock effect in our experimens
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