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《Journal of Peking University(Health Sciences)》 1988-04
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Department of Pharmacology Liao Jie, Zhang Bao-heng  
Oxymatrine (OMT) is an alkaloid isolated from Sophora alopecuroides L. The LD50 of OMT in mice by intramuscular injection was found to be 256.74±57.36 mg/kg.OMT (im) could diminish markedly ear inflammation in mice and rats induced by croton oil, and hind paw edema in rats induced by k-carrageenin. After intramuscular injection of OMT (51 and 85 mg/kg per day) and hydrocortisone (150 mg/kg per day) for 8 days in rats, the ear inflammation in rats induced by croton oil was decreased with anti-inflammatory rate of 42.71% (p0.005), 46.67% (p0.001) and 76.06% (p0.001) respectively. 30 min鹴es after intramuscular injection of OMT (85mg/kg) and hydrocortisone (200mg/kg) in mice, the inflammation by acetic acid (ip) shown by infiltrra tion of Even's blue dccreased singnifkantly, anti-inflammatory rate being 25.3%(p0.05), 38.5% (p0.001) and 67.4% (p0.001) respectively.In mice, extirpation of adrenal glands did not influence the anti-inflammatory effect of OMT It is suggested that its effect js not related to the hypoth-alamic adrenals system. Protein denatuiation and red blood celi hemolysis with heat in vitro could be inhibited by OMT. In chronic inflammation experiments, OMT had no effect on cotton pellets in rats while hydrocortisone had marked effect. The result suggests that OMT exhibits the characteristics of nonsteroid anti-inflammatory agents.
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