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《Journal of Peking University(Health Sciences)》 1988-04
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ANTI-INFLAMMATORY EFFECTS OF OXYMATRINE

Department of Pharmacology Liao Jie, Zhang Bao-heng  
Oxymatrine (OMT) is an alkaloid isolated from Sophora alopecuroides L. The LD50 of OMT in mice by intramuscular injection was found to be 256.74±57.36 mg/kg.OMT (im) could diminish markedly ear inflammation in mice and rats induced by croton oil, and hind paw edema in rats induced by k-carrageenin. After intramuscular injection of OMT (51 and 85 mg/kg per day) and hydrocortisone (150 mg/kg per day) for 8 days in rats, the ear inflammation in rats induced by croton oil was decreased with anti-inflammatory rate of 42.71% (p0.005), 46.67% (p0.001) and 76.06% (p0.001) respectively. 30 min鹴es after intramuscular injection of OMT (85mg/kg) and hydrocortisone (200mg/kg) in mice, the inflammation by acetic acid (ip) shown by infiltrra tion of Even's blue dccreased singnifkantly, anti-inflammatory rate being 25.3%(p0.05), 38.5% (p0.001) and 67.4% (p0.001) respectively.In mice, extirpation of adrenal glands did not influence the anti-inflammatory effect of OMT It is suggested that its effect js not related to the hypoth-alamic adrenals system. Protein denatuiation and red blood celi hemolysis with heat in vitro could be inhibited by OMT. In chronic inflammation experiments, OMT had no effect on cotton pellets in rats while hydrocortisone had marked effect. The result suggests that OMT exhibits the characteristics of nonsteroid anti-inflammatory agents.
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【References】
Chinese Journal Full-text Database 10 Hits
1 BI Yun-chen et al (School of Life Science,Shandong Normal University,Jinan,Shandong 250014);Research Advances on Antimicrobial Components in Leguminosae Plants[J];Journal of Anhui Agricultural Sciences;2009-09
2 Chen Xiaosong, Wang Guojun, Cai Xiong, Yu Hongyu, Hu Yiping (Department of Infectious Disease,Changzheng Hospital, Second Military Medical University, Shanghai, 200003);Oxymatrine downregulate HBV gene expression in HBV transgenic mice[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-10
3 FAN Li-qun(College of Primary Education,Xingtai University,Xingtai Hebei 054001,China);The prevention of the herbal medicines to cercaria of Schistosoma japonicum[J];Journal of the Hebei Academy of Sciences;2008-01
4 SHANG Lei,WANG Ling,SUN Hong-li,et al (Department of Pharmacology,Harbin Medical University,Bio-pharmaceutical Key Laboratory of Heilongjiang Province,Harbin 150086,China);Protective effects of oxymatrine on acute myocardial ischemia in rats[J];Journal of Harbin Medical University;2005-02
5 SUN Jing-wen,ZHANG Wei (Department of Laboratory Medicine,Nankai Hospital,Tianjing 300384,China);Study on Effects of Compound Kushen Injection on NF-kB of Macrophage[J];Journal of Medern Laboratory Medicine;2005-05
6 LiQing ,WangJin ,MaoXiaojie,ShaoChunli,LiuHui,WangShijiu DepartmentofPharmacy ,ShenyangPharmaceuticalUniversity ,Shenyang 110 0 15;Studies on the Cardiotonic Activities of Oxymatrine[J];JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY;1999-04
7 Wang Jin,Li Qing,Kan Qiming,Mao Xiaojie,Wang Shijiu Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015;Studies on the Hemodynamics of Oxymatrine[J];JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY;2000-02
8 DI Da-lin~1,LI Fa-qing~2,CHEN Lei~3,LIU Guo-jing~3(1.Immune Department of Weifang Medical College,Weifang 261042,China;2.The Pharmacology Department of Weifang Medical College,Weifang 261042,China;3.The Hospital Affiliated to Weifang Medical College,Weifang 261042,China);Study on Growth Inhibition Effect of Radix Sophorae Flavescentis on Bacteria in vitro[J];LiShiZhen Medicine and Materia Medica Research;2006-10
9 Li Shao, Lu Aiping,Jia Hongwei (Institute of Bioinformatics of Tsinghua University, Beijing 100084);The Curative Effects of Cold and Heat Chinese Herbal Formula on the Physical Sign and Synoviocytes of Collagen Induced Arthritis Rats[J];Chinese Journal of Information on TCM;2002-03
10 WU Guo-dong,WANG Ling.(Department of Microbiology and Immunology of Kunming Medical College,Kunming 650031,China);Study Progress of Antituberculous Chinese Traditional Medicine[J];Medical Recapitulate;2007-06
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhao Boguang (Yanchi Pharmaceutical Factory, Ningxia);STUDIES ON THE ALKALOIDS OF SOPHORA ALOPECUROIDES L.[J];Acta Pharmaceutica Sinica;1980-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Zhen-de 1,2;ZHU Lin1;ZHAO Bo-guang1;FANG Jie1.1 College of Forest Resources and Environment, Nanjing Forestry University, 210037, P. R. China;2 Forestry College, Guangxi University, Nanning, 530004, P. R. China.;Effects of alkaloids from Sophora alopecuroids on the activities of digestive and protective enzymes in Clostera anastomosis.[J];Journal of Beijing Forestry University;2006-01
2 LIU Fen, LIU Jie,WANG Qiu-jing,CUI Wen-peng,CHEN Xia ,LI Qiu-shi △ (Department of Pharmacoclogy,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Effects of oxymatrine on blood pressure in rats[J];Journal of Jilin University of (Medicine Edition);2005-03
3 ZHAO Dong-li,CHEN Hong-bo,NIE Xiu-wan ,WANG Kin-yu ,ZHENG Guo-chang (1 Institute of Cell Biology, Lanzhou University,Lanzhou 730000,China;2 Medical College,Dalian University,Dalian,Liaoning 116622,China);The effect of additional ultrasonic treatment on genetic transformation of Sophora alopecuroides mediated by Agrobacterium rhizogenes[J];Acta Botanica Boreali-occidentalia Sinica;2003-03
4 LI Xiao-ping,DING Jian-hua(Department of Biology,Huaibei Coal Industry Teachers College,235000,Huaibei,Anhui,China);The Effects of Cytisine on the Growth and Development of Anhui 19 Wheat[J];Journal of Huaibei Industry Teachers College (Natural Sciences Edition);2004-02
5 YU Dong-bo,LI Wen-jin,ZHAO Bo-guangNanjing Forestry University,210037 Nanjing,China;Field Trials of Application of the Active Leaf Fertilizer "Yezhuang" on Tea Leaf Productivity[J];China Forestry Science and Technology;2009-03
6 GENG Jing-zhang, XU Fu-xing (College of Biological Science and Engineering, Shanxi University of Technology, Hanzhong 723001, China);Progress in extraction and purification of alkaloids[J];Cereals & Oils;2007-04
7 Zhao Boguang\ Jiang Jihong (Nanjing Forestry University\ Nanjing 210037);SUBSTANCES FROM SOPHORA ALOPECAROIDES WHICH INHIBIT GERMINATION OF THE CONIDIA IN GLOMERALLA CINGULATA[J];SCIENTIA SILVAE SINICAE;1999-05
8 Zhao Boguang Liu Xiuhua Cheng Xiaoping Pan Yicheng (Nanjing Forestry University Nanjing 210037);Promoting Effects of the Total Alkaloids of Sophora alopecuroides on Tree Growth[J];Scientia Silvae Sinicae;2004-02
9 Yang Zhende~ 1,2 Zhu Lin~1 Zhao Boguang~1 Fang Jie~1(1.College of Forest Resources and Environment, Nanjing Forestry University Nanjing 210037; 2.Forestry College, Guangxi University Nanning 530004);Antifeedant Effects of Alkaloids from Sophora alopecuroids on the Feeding Behavior of Plagiodera versicolora[J];Scientia Silvae Sinicae;2006-07
10 Zhao Boguang (Naming Forestry University Naming 210037);NEMATICIDAL ACTIVITY OF ALOPERINE AGAINST PINE WOOD NEMATODES[J];SCIENTIA SILVAE SINICAE;1996-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LUO Chong et al (School of Geography and Biology, Guizhou Normal University,Guiyang,Guizhou 550001);Study on Effect of Plant Leaf on the Control of Bacteria[J];Journal of Anhui Agricultural Sciences;2005-05
2 Wu Jingde et al(Rice Institute,Anhui Academy of Agricultural Sciences,Hefei 230031);Analysis of Photosynthetic Efficiency in Maize Rice[J];JOURNAL OF ANHUI AGRICULTURAL SCIENCES;1997-02
3 ZHOU Wei-ren LI You-qin XUE Fei FAN Lei (Institute of Feed an d Food, Jiangsu Academy of Agricultural Sciences, Nanjing 210014);Distribution and Content Determination of Total Alkaloid in Sophora flavescens Ait[J];Amino Acids & Biotic Resources;2001-02
4 TAN Lin (Department of Hepatic Diseases,Fuyang Second People's Hospital,Anhui 236015 ,China);Treatment with matrine and/or levamisole in chronic hepatitis B[J];Journal of Bengbu Medicine College;2003-01
5 Ying Kang,Wang Yuzhen (Department of Biology,Baotou Medical College,Baotou 014010,China);The Effect of Paeomy Phenol on Transformation of Lymph Cells of Mice[J];Journal of Baotou Medical College;2001-02
6 Shi Changyong (Liaoning Academy of TCM, Liaoning);Elaboration of Treatise on Collateral Disease[J];;1992-04
7 Shi Changyong (Liaoning Academy of TCM, Liaoning);Treatise on Collateral Disease & Microcirculation[J];;1992-05
8 Deng Zhaozhi et al.(TCM Hospital of Guangdong Province, Guangdong);A Discussion on the Syndromes of Rheumatoid Arthritis[J];;1993-06
9 Wang Weilan et al.(Beijing Hospital of TCM, Beijing);Research on Acute Attack of Rheumatoid Arthritis Treated with Decoction of Reinforcing Yin, Clearing up Heat and Removing Dampness[J];China Journal of Traditional Chinese Medicine and Pharmacy;1994-02
10 Lin Zhi-bin;Chai Bao-ling;Wang Pei;Guo Qian-xin;Lu Fu-sun;Xiang Gui-qiong Department of Pharmacology and People's Hospital, Beijing Medical College Beijing Institute of Botany, Academia Sinica;STUDIES ON THE ANTI-INFLAMMATORY EFFECT OF CHEMICAL PRINCIPLE OF ZI-CAO [ARNEBIA EUCHROMA (ROYLE) JOHNST][J];;1980-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 BI Yun-chen et al (School of Life Science,Shandong Normal University,Jinan,Shandong 250014);Research Advances on Antimicrobial Components in Leguminosae Plants[J];Journal of Anhui Agricultural Sciences;2009-09
2 XU Bin~1,ZHOU Shuang-cheng~1,HUANG Yu-xian~2,QU Di~1(1.Key Laboratory of Medical Molecular Virology,Ministry of Education and Public Health of P.R.China,Institute of Medial Microbiology/Institute of Bio-medical Science,Fudan University,Shanghai 200032,China;2.Department of Infectious Diseases,Huashan Hospital,Fudan University,Shanghai 200040,China);Study of Anti-Duck Hepatitis B Virus Effects of Oxymatrine Using Primary Duck Hepatocyte Culture System[J];Chinese Journal of Virology;2006-05
3 SHEN Yi-hong1 ZHU Jian2 LI Jing2(1.College of Biotechnology,Southwest University,Chongqing 400716,China;2.College of Pharmaceutics,Southwest University,Chongqing 400716,China);Research and Application of Plant Alkaloids in Medicine[J];Newsletter of Sericultural Science;2008-01
4 He Hongbo, Wu Guangqian, Liu Hong, et al. Department of hemorrhoids and fistula, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041;Clinical Efficacy of Zhixue Capsule in the Treatment of Ⅰ,Ⅱdegree Internal Hemorrhoids[J];Journal of Colorectal & Anal Surgery;2006-01
5 XU Wen-Sheng, WANG Guo-Jun, MIAO Xiao-Hui, CAI Xiong (Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China);Effects of oxymatrine on expression of HBV DNA in HepG2.2.15 cells[J];Academic Journal of Second Military Medical University;2002-01
6 Yang Xiao-ming Xu Hua Wang Tian (Department of pathophysiology,Ningxia Medical College,Yingchuan 750004,China);The Investigation about Protective Mechanism of Oxymatrine on Cardiac Function in Rats with Myocardial Injury[J];Chinese Journal of Medicinal Guide;2007-02
7 Chen Huaixia,Han Fengmei,Du Peng,Chen Yong~*(The Provincial Key Laboratory of Bio-Technology of Traditional Chinese Medicine,Hubei University,Wuhan 430062);Electrospray Ionization Mass Spectrometry for Analyses of Alkaloids in Sophoraflavescens Ait.[J];Chinese Journal of Analytical Chemistry;2006-02
8 Bai Xiao-Hong,Yang Xue,Chen Xuan,Wang Lin-Hui(Department of Pharm,Shanxi Medical University,Taiyuan 030001);Determination of Oxymatrine and Matrine by Liquid Phase Microextraction with Back Extraction Coupled with High Performance Liquid Chromatography[J];Chinese Journal of Analytical Chemistry;2008-02
9 Wang Xiang (Shaanxi Pharmaceutical Corp For Foreign Economy and Technology Cooperation) Wang Baoqi, Pang Zhigon, Zhao Jianxing (Pharmacy College,Xi'an Medical University, Xi'an,710061);Monitor the Blood Drug Concentration of Matrine and Oxymatrine by Fluorescence Quenching[J];JOURNAL OF ANALYTICAL SCIENCE;1998-04
10 Yang Yun ,Pang Zhigong and Wang Baoqi (Department of Pharmacy,Xi'an Medical University,Xi'an 710061);Distribution of Matrine in Rabbit Viscera by Quenching Fluorescence Method[J];ANALYTICAL LABORATORY;1998-06
China Proceedings of conference Full-text Database 1 Hits
1 Yinghua Sun,Xiaohong Liu,Lei Li,Jin Sun,Zhonggui He;Preparation of the sustained-release systems of kushenin and study on the relative bioavailability[A];[C];2008
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