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Department of Pharmarcognosy Qi Zhi, et al  
The efl'ects of the volatile oil from the Chiaese drug Wuweizi, the dried fruit of Schisandra chinensis Baill, on thc central nervous system and its acute toxieny were mvestigated. The volatile oil significantlv shortened the sleeping time of mice ehcited by pcntebarbital and showed no synergistic effect with citlher cardiazol or strvchnine. But it increased the content of hepatic cytochrome P-450 in mice. At doscs of 0.24g kg and 0.71g kg, it induced a decrease of thc activity of mice. It is therefore considered that the mcchanism of sherteaing thc slccping time is due to the effect of the volatile oil in inducing the enzymes rcsponsible for metabolizing drups. I.D. of the volatile oil given to mice P. O. was found to be 8.75 2.41g kg.
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