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《Journal of Peking University(Health Sciences)》 1989-04
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EFFECT OF POLYSACCHARIDE OF ACANTHOPANAX SENTICOSUS (PAS) ON IMMUNOLOGICAL RECONSTITUTION OF ALLOGENEIC BONE MARROW TRANSPLANTATION IN MICE

Department of Immunology Xie Shusheng  
In this communication the anti-Thy-1.2 monoclonal antibody plus complement were used to purge T cells from allogenic bone marrow. The T-cell-depleted allogeaeic bone marrow successfully reconstituted the immunological functions of the lethally irradiated BALB/c mice.On the forty-fifth day after allogeneic bone marrow transplantation the immunologically reconstituted BALB/c mice were injected with PAS at dosage of 100mg/kg/day i.p for 10 days. The PFC response to thymus-independent antigen TNP-Ba and the mitogenic response to ConA and LPS were significantly increased in drug-receiving group but no increase of PFC response to thymus-dependent antigen SRBC and DTK response induced by BSA was observed.
【Fund】: 国家自然科学基金
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