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《Journal of Peking University(Health Sciences)》 1993-02
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Yin Jinzhu Department of Immunology  
Studies in mice, we have demonstrated that (1) Neither SFA product nor OXY has any influenceon IgE antibody response in vivo. (2) OXY i?ibited the histamine release from peritoneal mast cellsinduced by anti-DNP IgE and TNP-KLH in a dose dependent manner. Further studies have shownthat the inhibitory effects are probably neither due to the blocking. of specific binding of antigen andantibody, nor due to the changing of cellular lever of cAMP. However, when P815 cells were incuba-ted with the effective concentration of OXY, the fluidity of cellular membrane was decreased, sugges-ting that the histamine release inhibitory effects of OXY might result from the stabilizing activity ofcellular membrane and this characteristic of OXY might be the pharmacologic basis that made it asuccessful therapy of allergic diseases.
【Fund】: 自然科学基金
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