CIRCULATING ENDOTOXIN PROMOTES THE TRANSPORT OF GUT-DERIVED ENDOTOXIN AND THE EFFECT OF SELECTIVE BOWEL DECONTAMINATION
Wang Weiyang Department of Physiology
The pathophysiological changes induced by intravenous injection of a single dose of LPS from E.Coll (5mg/kg) and the effects of oral ampicillin prophylaxis for selective bowel decontamination onthe changes induced by endotoxin in the rat in vivo and in isolated, vascularly perfused ileal prepara-tion were observed. It was found that LPS significantly promoted the transport of gut-derived endoto-xin, and induced intestinal and hepatic tissue injury, hypoglycemia and elevated plasma endothelin andcalcitonin gene-ralated peptide level. These results suggested that there exists a positive feedback rela-tionship between circulating and gut-derived endotoxin. Oral ampicillin prophylaxis for selective boweldecontamination did not significantly improve the pathophysiological changes induced by endotoxin, norexerted any effect on the mortality.
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