CHANGES IN PLASMA GLUCAGON LEVEL IN DIABETIC PATIENTS AND THEIR CLINICAL SIGNIFICANCE
Wang Lewei,et al Department of Endocrinology,People’s Hospital
The fasting plasma glucagon level was measured in 39 normal subjects, 13 IDDM and 44 NIDDMpatients. The results showed that the glucagon level in both IDDs and NIDDs was significantly higherthan that in normal subjects (P0.001). In addition, 18 normal subjects and 30 NIDDM patientsunderwent a steamed-bread meal test, and the changes in glucagon level was also studied. The glucagonlevel in NIDDM patients was significantly elevated after the meal (P0.05 or less), but in normalsubjects there was no significant change (P0.05). Whereas the glucagon levels before and after themeal in NIDDs were significantly higher than those in normal subjects (P0.05 or less). The rise ofinsulin/glucagon ratio in NIDDs was retarded and much lower that that in normal subjects (P0.01 orless) The results indicate that there exists dysfunction of islet a-cells in diabetic patients, and it maycontribute to hyperglycemia. Insulin/glucagon ratio may be a more perfect index than sole insulin me-asurement in reflecting the pathophysiological state of diabetes mellitus.