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《北京医科大学学报》 1997-06
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ACUTE AND 14 DAY REPEATED DOSING TOXICITY OF NIUHUANG JIEDU PIAN IN RATS

FU Liling; ZHOU Zongcan; GONG Encong; WANG Yue; ZHANG Kuihan(University Hospital of Beijing Medical University 100083)  
Objective: To examine the acute and 14 day repeated oral dosing toxicity of Niuhuang Jiedu Pian in rats Methods: Acoording to " Guideline on study for new Chinese traditional drug (pharmaceutics,phamacology and toxicology), 1994". Results: Wistar rats wer dosed by single gavage with Niuhuang Jiedu Pian at 6. 43 g/kg (equel to 50 times of clinical dose) and no rat dead. In the 14 day repeated oral dosing toxicity test, rats of 6. 43 g/kg and 3. 21 g/kg groups had a low increase in body weight and pathological liver damage. Conclusion: The oral LD50 of Niuhuang Jiedu Pian for rats was more than 6. 43 g/kg. In 14 day repeated dosing test in rats, toxicity threshold of Niuhuang Jiedu Pian was 3. 21 g/kg (equel to 25 times of clinical dose) and the target organ was liver.
【CateGory Index】: R285
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