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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 1999-05
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Hypoglycemic effects of insulin loaded nanoparticles by pulmonary delivery to normal rats

SHEN Zan Cong #, ZHANG Qiang,WEI Shu Li (# Department of Pharmaceutics,Beijing Medical University,Beijing 100083)  
Objective:To investigate the hypoglycemic effects of insulin loaded nanoparticles (INS NP) after pulmonary delivery to rats. Methods:The pulmonary delivery model was established in normal rats. Blood glucose levels were measured using glucose oxidase method (GOD) to evaluate the hypoglycemic effects .Results:After 5, 10, and 20 u·kg -1 of INS NP were administered from the lung,The duration below 70% level (DBL 70% ) of 5 u·kg -1 INS NP was approximately the same as that of its control solution,while 10 u·kg -1 and 20 u·kg -1 INS NP had greater DBL 70% values than their control (INS SOL) .The relative pharmacological bioavailability of INS NP reached 59.2%. Conclusion: Pulmonary delivery of INS NP to rats can significantly prolong the duration of hypoglycemic effect.
【Fund】: 天然药物与仿生药物国家重点实验室资助
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【References】
Chinese Journal Full-text Database 1 Hits
1 LI Wei~1,HUANG Mei,LIU Xin-an~2(1.Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing university of medical Sciences, Chongqing 400016, China 2.Environmental & Chemical Engineering Institute, Chongqing University, Chongqing 400044, China);Preparation of 5-Fluorouracil-loaded Nanocapsules[J];Huaxue Shijie (Chemical World);2004-01
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Qiang, DING Jijun, WEI Shuli (Department of Pharmaceutics, Beijing Medical University, Beijing 100083);PROPERTIES AND HYPOGLYCEMIC EFFECT OFTHE INSULINLOADED NANOPARTICLES FOR ORAL ADMINISTRATION[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1998-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Zhang Huashan Biological engineering department of Hubei polytechnic university Wu chang (430068);The Enzymatic Hydrolysis of Protein in Blood Procine and the Content of amino acid in the hydiolysate[J];AMINO ACIDS & BIOTIC RESOURCES;1999-03
2 WANG Jie 1, ZHANG Qiang 1, YI Xiang 1, CAO Dong 2, LI Hong Shan 1, WEI Shu Li 1 (1 Department of Pharmaceutics, 2 Department of Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China);Effect of surface modification on the uptake of polylactic acid nanoparticles loading cyclosporine A by cells in vitro and on the body distribution in vivo[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;2000-03
3 ZHANG Qi 1, DENG Ying Jie 2,LUO Guo An 1△ (1. Chemical Department of TsingHua University, Beijing 100084,China; 2. Pharmacy Department of Shenyang Pharmaceutical University);Uniform design method used in the preparation of liposomal 5-FU and the stabilities[J];Journal of Beijing Medical University;2002-01
4 WANG Zhiying, ZHANG Qiang △ (Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China);Study on pulmonary delivery system of salmon calcitonin in rats[J];Journal of Beijing Medical University;2003-03
5 ZHENG Ai-ping ▲, YU Shao-yun, ZHAO Ying,WU Feng-lan △ (Department of Pharmaceutics, Peking University School of Pharmaceutical sciences, Beijing 100083, China);Preparation and properties of 5-fluorouracil-loaded chitosan microspheres for the intranasal administration[J];Journal of Peking University(Health Sciences);2004-03
6 ZHANG Qiang, DING Jijun, WEI Shuli (Department of Pharmaceutics, Beijing Medical University, Beijing 100083);PROPERTIES AND HYPOGLYCEMIC EFFECT OFTHE INSULINLOADED NANOPARTICLES FOR ORAL ADMINISTRATION[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1998-03
7 YIN Cheng-hui 1, HOU Chun-lin 2* , XU Hao 1, GUO Cheng 3, ZHANG Chun 3, JIANG Li-xia 4, GU Qi-sheng 4 (1. Department of Orthopeadics, General Hospital, PLA Nanjing Military Area Command,Fuzhou 350025, China; 2. Department of Orthopeadics, Changzheng Hospital, Second Military Medical University,Shanghai 200003; 3. Department of Pharmacy, Changzheng Hospital, Second Military Medical University,Shanghai 200433;4. Shanghai Qisheng Bio-Material Technological Institute,Shanghai 201106);Prevention and treatment of local infection using implantable sustained release ciprofloxacin/carboxmethyl chitosan microspheres[J];Academic Journal of Second Military Medical University;2005-01
8 YANG Cai Zhe 1,HU Jia Lu 2,XU Liang 2, WU Dao Cheng 3, ZHANG Xue Yong 2 1Department of Endocrinology, Chinese PLA General Airforce Hospital, Beijing 100036,China, 2Institute of Gastroenterology, Xijing Hospital, 3Department of Ch;Hypoglycemic effect of insulin-nanoparticles on diabetic rats[J];Journal of The Fourth Military Medical University;2001-08
9 Liu Zhanjie, Hua Zezhao, Tao Leren , Liu Baolin (Institute of Refrigeration and Cryogenic Engineering, Shanghai University of Science and Technology, Shanghai 200093);THE EFFECT OF CRYOPROTECTANT CONCENTRATION AND COOLING RATE ON THE GLASS TRANSITION TEMPERATURE OF LIPOSOME[J];Gryogenics;2000-06
10 FU Haiying YAO Side WU Guozhong (Radiation Application Center, Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800);RADIATION INDUCED DEGRADATION OF SODIUM ALGINATE[J];Journal of Radiation Research and Radiation Processing;2003-03
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 REN Jie,YU Xiao,REN Tianbin,YUAN Hua(Institute of Nano and Bio-Polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai 200092);Preparation and Characterization of Norcantharidin Loaded Sustained-release Poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) Nanoparticles[J];Materials Review;2006-06
2 FAN Run-zhen,WAN Yi-ling,SONG Wen-dong (Science College of Guangdong Ocean University,Zhanjiang 524025,China);Microcapsule characteristics of econazole nitrate[J];Journal of Guangdong College of Pharmacy;2006-02
3 WU Wenguo1,HUANG Xiaonan1,WANG Shibin1,2,NI Sha1,LIU Yuangang1(1School of Chemical Engineering,Huaqiao University,Xiamen 361021,Fujian,China;2 Institutes of Pharmaceutical Engineering,Huaqiao University,Xiamen 361021,Fujian,China);Preparation of calcium alginate/poly-L-histidine microcapsules by emulsification[J];Chemical Industry and Engineering Progress;2009-04
4 ZHANG Heng,JI Xiu-li(School of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,Shandong,China);Progress on Materials,Preparation and Characterization of Biodegradable Nanocapsules[J];Synthetic Materials Aging and Application;2008-03
5 LI Wei~1,LIU Xin-an~2(1.Research Laboratory of Pharmaceutical Chemistry and Biomaterials,Chongqing University of Medical Sciences,Chongqing 400016,China;2.Chemical Engineering Institute,Chongqing University,Chongqing 400044,China);Characterization of 5-Fluorouracil Loaded Nanospheres[J];Fine Chemicals;2006-06
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