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Alterations of heme oxygenase in cardiovascular system during sepsis

LI Yu Ming, LIU Jun Chang, ZHANG Min, ZHENG Xin Cheng, WU Li Ling, SHI An Yun, et al (Department of Pathophysiology, Beijing Medical University, Beijing 100083)  
Objective: To study the alterations of heme oxygenase(HO) in cardiovascular system during sepsis. Methods: A rat sepsis model was induced by cecal ligation and puncture. In early and late sepsis, mean blood pressure(MBP),left ventricular function parameters and blood plasma lactate dehydrogenase (LDH) were measured. Then HO activities and MDA contents of the heart and aorta were examined. HO 1 mRNA expression was examined by Northern Blot. Results: In early sepsis, HO activity in the heart increased by 72.1% ( P 0.01)compared with control;while HO activity in the aorta, MBP, left ventricular function and blood plasma LDH had no significant changes. MDA contents in the heart and aorta increased by 60.3% and 96.5% respectively( P 0.05).In late sepsis,HO activity in the heart was still maintained at the high level while that in the aorta increased by 261% ( P 0.01)compared with that in early sepsis MBP,left ventricular function decreased and blood plasma LDH and MDA contents in the heart and aorta increased significantly ( P 0.01).HO 1 mRNA expression in the heart was the same as the alteration tendency of HO activity but that in the aorta was increased by 49.2% ( P 0.05) and 143% ( P 0.01) respectively in early and late sepsis. Conclusion: HO activity and HO 1 mRNA expression in the heart and aorta are increased during sepsis and the inducable HO plays an important role during sepsis.In early sepsis HO can protect organs from injury but in late sepsis it may be one of the most important reasons for hypotension.
【Fund】: 国家自然科学基金
【CateGory Index】: R362
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