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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 2000-02
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Study on the chronic obstructive palmonary disease: M_2 receptor in patients with chronic obstructive palmonary disease

YAO Wan Zhen, LIU Ya, HAN Xiang, WANG Guo Yang, LIU Xiao Fang, CHEN Ya Hong (Department of Respiratory Medicine, the Third Hospital, Beijing Medical University, Beijing 100083, China)  
Objective: To investigate the M 2 receptor (M 2 R) function in patients with chronic obstructive palmonary disease (COPD). Methods: 10 healthy volunteers and 8 patients with COPD were included in the study. They were randomly divided into two groups: 1. BPT (bronchial provokative test) BPT after inhaling pilocarpine; 2. BPT after inhaling pilocarpine BPT. There was a 7 day interval between the two BPTs. The change of FEV 1, D min and R value during pre-pilocarpine and post-pilocarpine were calculated. Results: D min in volunteers was 195% higher during post pilocarpine than that of pre pilocarpine( P 0.01). There was no significant change of FEV 1, D min and R value in patients with COPD during pre-pilocarpine and post-pilocarpine( P 0.05). Conlusion: There was a airway M 2 R dysfunction in patients with COPD.
【CateGory Index】: R563.9
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