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《Journal of Beijing Medical University》 2001-01
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Expression and distribution of laminin in the mouse embryos during early development

LI Ying, LU Dan Yu, YANG Jing Jing (Department of Histology and Embryology,Peking University School of Basic Medical Sciences,Beijing 100083,China)  
Objective: To study the expression and distribution of laminin(LN) in the mouse early embryos during the various stages of development. And to inquire further the relationship of LN with embryo differentiation and implantation of blastocyst. Methods: Indirect immunofluorescence technique and immunohistochemical ABC method were used to observe LN in mouse early embryos during the various stages of development. Results: Strong immunofluorescence or brown granules for LN staining were found in the blastomere of pronucleus stage, two cell to eight cell stage, but not in the extracellular matrix. In morula, positive LN immunoreactive substance appeared simultaneously in both blastomere and extracellular matrix. LN chiefly distributed in the inner cell mass and between trophoblasts in early blastocyst. When it was later blastocyst, LN expression was enhanced in trophoblast cells, but not in the extracellular matrix. And strong positive LN immunoreactive substance was also found in the inner cell mass and polar trophoblast cells. Conclusion: LN existed in the blastomere during early mouse embryo development; LN appeared in extracellular matrix in morula; LN in the polar trophoblast cells and inner cell mass increased when blastocyst intruded into endometrium; LN in early mouse embryos was related to embryo development, attachment and implantation.
【Fund】: 国家自然科学基金资助! ( 39370 371;;30 0 79791&&
【CateGory Index】: Q954.4
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