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《Journal of Beijing Medical University》 2001-04
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L-arginine regulates hypoxic pulmonary vascular structural remodeling and pulmonary artery smooth muscle cell apoptosis in rats

QI Jian Guang 1, DU Jun Bao 1, GUO Zhi Liang 1, ZHAO Bin 2, ZHANG Qin You 1,ZENG He Ping 1, TANG Chao Shu (1 Department of Pediatrics, 3. Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China; 2  
Objective: To explore the impact of L arginine ( L Arg ) on apoptosis of smooth muscle cells in pulmonary arteries of the rats with hypoxic pulmonary vascular structural remodeling. Methods: Seventeen Wistar rats were randomly divided into hypoxia group ( n =5 ), hypoxia with L arginine group ( n =5 ) and control group ( n =7 ). Pulmonary vascular microstructure was measured under a light microscope. Apoptotic smooth muscle cells in pulmonary arteries were detected by TdT mediated dUTP biotin nick end labeling ( TUNEL ), and the expression of Fas protein by pulmonary artery smooth muscle cells was detected using immunohistochemistry technique. Results: Pulmonary vascular structural remodeling developed after 2 week hypoxia. Meanwhile, the percentage of apoptotic smooth muscle cells in pulmonary arteries was markedly decreased in hypoxic rats compared with normal controls ( P 0.05 ). The expression of Fas protein of hypoxic rats was inhibited obviously. L arginine ameliorated pulmonary vascular structural remodeling of hypoxic rats in association with an increase in the percentage of apoptotic smooth muscle cells in pulmonary arteries and a strengthened Fas expression by pulmonary artery smooth muscle cells. Conclusion: L arginine plays an important role in the regulation of development of hypoxic pulmonary vascular structural remodeling throughpromoting Fas expression and thereby apoptosis in pulmonary artery smooth muscle cells.
【Fund】: 国家自然科学基金 (39470 735 ;;39870 844);; 国家重点基础研究项目 (973)基金 (G2 0 0 0 0 5 6 90 5 )&&
【CateGory Index】: R364.4
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