P2Y purinoceptor-mediated signal transduction pathway in regulation of growth and metastasis of prostate carcinoma

FANG Wei Gang, LI Hong Mei, ZHENG Jie, WU Bing Quan (Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100083, China)  

The most frequent cause of death for cancer patients is metastasis. The precise molecular events leading to the acquisition of malignant phenotypes remain largely unknown. During the past 10 years, we have focused our efforts on exploring signaling mechanisms underlying malignant progression of human prostate carcinoma. We found that activation of P2Y purinoceptor on androgen independent prostate carcinoma cell lines resulted in significant growth inhibition. This growth inhibitory effect was accompanied by activation of phospholipase C and calcium mobilization, and proved receptor specific. We also demonstrated that the G protein coupled P2Y purinoceptor was linked to Erk1/2 and p38 MAPK pathway, and there existed cross talk between phospholipase C and MAPK pathways. We found Erk1/2 and p38 MAPK pathways were differentially activated between metastatic and non metastatic prostate carcinoma cell subclones, providing valuable clue to further study molecular mechanism of tumor metastasis.

【Key Words】： Signal transduction/genet Prostatic neoplasms/genet Neoplasm metastasis/genet
【Fund】： 国家自然科学基金 ( 392 0 0 14 2 );; ( 30 0 70 2 93) ;; 北京市自然科学基金 ( 70 0 2 0 2 2 )资助~~
【CateGory Index】： R737.25

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