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《Journal of Beijing Medical University》 2002-01
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Preparation and characterization of long-circulating solid lipid nanoparticles containing paclitaxel

CHEN Da Bing, LU Wan Liang,YANG Tian Zhi, LI Jing, ZHANG Qiang (Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China)  
Objective: To prepare long circulating solid lipid nanoparticles containing paclitaxel with stearic acid. Methods: The stearic acid solid lipid nanoparticles containing paclitaxel were prepared by the method of "emulsion evaporation solidification at low temperature". Its morphology was examined by transmission electron microscope. The HPLC method for determination of paclitaxel in nanoparticles or blood samples was established. The release of paclitaxel in vitro and the pharmacokinetics after iv bolus injection to mice were studied. Results: Long circulating nanoparticles containing paclitaxel had a mean diameter of 220 nm. Long circulation nanoparticles could stay in the blood circulation for a longer time, with an increased T 1/2β 10.1 h , against T 1/2β 2.3 h of conventional nanoparticles and T 1/2β 1.3 h of paclitaxel injection. Conclusion: The long circulating nanoparticles can pronouncedly increase the circulation time of paclitaxel in blood stream.
【Fund】: 国家自然科学基金 ( 39870 897)资助~~
【CateGory Index】: R942
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