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《Journal of Beijing Medical University》 2002-05
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Metallothionein- cardiovascular cytoprotective agent

YANG Jing-Hui, CHANG lin, TANG Chao-Shu △ (Department of Physiology and Pathophysiology,Peking University School of Basic Medical Sciences, Beijing 100083,China)  
Metallothionein (MT) is a low molecular weight no n-enzyme protein rich in L -cysteine. It widely distributes in various animal and plant species a nd pla ys important roles in detoxifying against harmful heavy metals, scavenging oxyen free radicals and stabilizing biomembranes. MT synthesis can be easily induced b y many factors. MT expression is up-regulated in stress and pathologic conditio n s such as inflammation, infection, shock, and tissue injury etc. In recent years , accumulating experiments with transgenic and gene knockout animal models have showed that MT is a kind of strong endogenous cytoprotective agent which plays importa nt roles in protecting against cardiovascular injury. Exogenous administration w ith MT or induced endogenous MT production may be used as a new strategy in prevent ion and therapy of cardiovascular diseases.
【Fund】: 国家自然科学基金 ( 3 9970 2 95 );; 国家重点基础研究发展规划项目 ( 973 )基金 (G2 0 0 0 0 5 690 5 )资助
【CateGory Index】: R972
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