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《Journal of Beijing Medical University》 2002-05
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Progress of studies on the anti-tumor activity and immunomodulating effect of Ganoderma

LIN Zhi-Bin △ (Department of Pharmacology,Peking University School of Basic Medical Sciences,B eijing 100083,China)  
Anti-tumor activity and immunomodulating effect of Ganoderma lucidum extract and Ganoderma lucidum polysaccharides and the ir mechanisms were reviewed in this paper. Ganoderma lucidum extract and Ga node rma lucidum polysaccharides significantly inhibited the implanted animal t umors in vivo However,both of them directly added to tumor cells cultured medium neither suppressed tumor cell proliferation nor induced its apoptosis.The anti- t umor activity of Ganoderma lucidum polysaccharides may be mediated by immun o logical mechanism in vivo . Recent studies indicated that Ganoderma lucidu m polysaccharide peptides had antioxidant effects by scavenging free radicals d erived from tert-butyl hydroperoxide(tBOOH) in macrophages in vivo and in vitro.Ganoderma lucidum polysaccharides was also shown to promote not only th e maturation of dendritic cells(DC) derived from the cultured murine bone marro w in vitro , but also the immune response induced by DC.
【Fund】: 国家自然科学基金 ( 3 860 0 97);; 高等学校博士学科点专项科研基金 ( 8910 )资助
【CateGory Index】: R285.5
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