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《Journal of Peking University(Health Sciences)》 2004-01
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Chemical constituents from chinese marine sponge Cinachyrella australiensis

LI Li ya 1, DENG Zhi wei 2,LI Jun 1,FU Hong zheng 1,LIN Wen han 1△ (1. State Key Laboratory of Natural and Biomemetic Drugs , Peking University , Beijing 100083,China; 2. Chemical Test Center, Beijing Normal University)  
Objective: To investigate the secondary metabolites from Chinese marine Sponge Cinachyrella australiensis. Methods: Column chromatography techniques including HPLC were used for the separation and purification of the compounds, and extensive spectral analyses including various 2D NMR spectra were employed for structure elucidation. Results: Nineteen compounds were obtained ,including 2 methyoxy 6,12,15 trien 8 yne octadecanoic acid(1), 2 benzenedicarboxylic acid dibutyl ester(2), 1,2 benzenedicarboxylic acid bis(2 ethylhexyl)ester(3), ( ) (3S) 1,2,3,4 tetrahydro β carboline 3 carboxylic acid(4), L Tryptophan (5), p hydroxylbenzaldehyde (6), p hydroxyl benzylethanol(7), p hydroxyl benzyl propanol(8), cholesta 4 en 3 ol(9), 2 methyl 6 amino 9 (2 deoxy β D ribofuranosyl purine(10), 2' Deoxyadenosine (11), 6 amino 9 β D ribofuranosyl 9H purine (12),uracil(13), thymine(14), thymidine(15), 1 (2 deoxy β D Ribofuranosyl)uracil(16), 1 ethyl α (2 deoxy) β D ribofuranos(17),isolumichrome(18),and zarzissine(19).Conclusion:Compounds 1 and 18 are new natural products,and compounds 2 to 17 as well as 19 are isolated from this species for the first time.
【Fund】: 国家高技术研究发展计划专项经费 ( 2 0 0 1AA62 40 3 0 ;2 0 0 2AA2 170 81);; 国家自然科学基金 ( 3 0 17110 6;40 1760 3 8)资助~~
【CateGory Index】: R284.1
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