Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Peking University(Health Sciences)》 2005-03
Add to Favorite Get Latest Update

Regulation of genistein on the levels of ERα, ERβ mRNA in uterine endometrial cancer cells

XUE Xiao-ou, WEI Li-hui △ (Department of Gynecology,Peking University People’s Hospital,Beijing 100044,China)  
Objective: To explore the mechanism of phytoestrogen (genistein) on uterine endometrial cancer cells and provide the theory foundation for using phytoestrogen in clinical practice. Methods: Uterine endometrial cancer cell lines (ishikawa) were cultured in vitro at different genistein concentration, and the expressions of the two estrogen subtypes of endometrial cancer cells were observed by real-time PCR. And two treatment groups, estradiol and progestin, were used as positive controls. Results:(1) Low concentration of genistein could enhance the expression level of ERα mRNA of endometrial cancer cells, which was obviously weaker than that of the estradiol group. On the other hand, low concentration of genistein could decrease the expression level of ERβ mRNA of endometrial cancer cells, however estradiol had hardly any effect on this .(2) High concentration of genistein could decline the expression levels of ERα and ERβ mRNA of endometrial cancer cells, whose effect was weaker than that of progestin. Conclusion: The expression levels of ERα mRNA and ERβ mRNA of endometrial cancer cells vary with genistein concentrations. The experimental results suggest that genistein may act as estrogen receptor regulator.
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 SUN Bing,ZHOU Li(Department of Gynecology, Affiliated Tumor Hospital, Shantou University Medical College, Shantou Guangdong 515041, China);Influence of Genistein on Uterine Endometrial Cancer Cell Line,Ishikawa[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-03
2 XUE Xiaoou,YANG Yi,AI Hao,et al. (Department of Gynecology,DongFang Hospital of Beijing University of Chinese Medicine,Beijing,100078 China);Protective effects of genistein on ovarian granulosa cell toxicity in normal female rats induced by cisplatin[J];Chinese Journal of Clinical Obstetrics and Gynecology;2007-01
3 XUE Xiaoou,WANG Yue,YANG Yi,et al.(Department of Gynecology,Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China);Induction of apoptosis by genistein in human endometrial carcinoma cell line HEC-1B and its mechanism[J];Chinese Journal of Clinical Obstetrics and Gynecology;2008-01
4 LIU Xiao-li,XUE Xiao-ou,TANG Bing-hua,NIU Jian-zhao(Dongzimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China);Effect of Daidzein on expression of fluorescein gene regulated by ERE in HEC-1B[J];Journal of Traditional Chinese Medicine University of Hunan;2011-01
5 GAO Min,CAO Yuan-kui,XUE Xiao-ou~# (Department of Gynecology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700);Effect of daidzein on proliferation of endometrial carcinoma[J];Journal of Beijing University of Traditional Chinese Medicine;2010-03
6 LIU Xiao-li,XUE Xiao-ou,TANG Bin-hua,NIU Jian-zhao(Department of Gynecology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700);Influences of genistein on proliferation of HEC-1B and expressions of luciferase reporter genes[J];Journal of Beijing University of Traditional Chinese Medicine;2011-04
7 LIU Xiao-li1,XUE Xiao-ou1,ZHAO Li-yun2,NIU Jian-zhao2(1.Department of Gynecology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;2.Institute of Basic Medical Science,Beijing University of Chinese Medicine,Beijing 100029,China);Effect of Daidzein on Proliferation of Endometrial Carcinoma and Its Mechanism[J];Chinese Journal of Information on Traditional Chinese Medicine;2011-10
8 WANG Da-wei,NIU Jian-zhao,WANG Ji-feng,SUN Li-ping(Laboratory of Cell Biochemistry,College of Basic Medicine,Beijing Universityof Traditional Chinese Medicine,Beijing 100029,China);Problems and countermeasure of screening studies on estrogen receptor modulators in Chinese materia medica[J];Chinese Traditional and Herbal Drugs;2009-05
China Proceedings of conference Full-text Database 1 Hits
1 ;植物雌激素作用机制的研究现状及有关进展[A];[C];2008
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Xue Xiaoou\+*,Wei Lihui,Niu Jianzhao,et al.\+*Department of Obstetrics and Gynecology,Peking University People's Hospital,Beijing 100044,China;Compare the effects of the two monomers of phytoestrogens on endometrium glandular epithelium cell.[J];Chinese Journal of Practical Gynecology and Obstetrics;2004-08
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Cheng1,CHANG Qing1,ZHANG Li-long2,AI Guo-Ping2(1Department of Gynaecology and Obstetrics,Southwest Hospital,2State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Combined Injury,College of Preventive Medicine,Third Military Medical University,Chongqing 400038,China);Biological effect of four isoflavone derivatives on proliferation of endometrial epithelial cells in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2008-16
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 JIANG Cheng-mei 1 ,ZHAO Wen-hong 1 ,ZHUANG Ying 1 ,LU He-zuo 2 (1.Department for Preventive Medicine of Bengbu Medical College,Bengbu233003,Anhui,China;2.Center for Immunology of Bengbu Medical College,Bengbu233003,Anhui,China);Differentiation of B_(16) Melanoma Cells Induced by Genistein[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-01
2 XIANG Qi-sen et al(College of Life Science,Northwest A&F University,Yangling,Shaanxi 712100);Summary of the Bioactive Component and Physiological Function of Phytoestrogen[J];Journal of Anhui Agricultural Sciences;2006-10
3 TANG Li-jian,ZHAO Liang-cai,SU Jing-jing,XIAO Feng,CHENG Hui,WANG Lei,ZHU Guo-qi,LI Qing-lin(Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);Study on the Antiprolerative Effects of Alcohol Extracts of Kudzu Root and Radix Scutellariae on Breast Cancer Cell Lines in vitro[J];Journal of Anhui Traditional Chinese Medical College;2006-06
4 JIN Hong,LIU Li, WANG Xian-yuan, XU Zhi-qin, NAN Wen-kao, LI Pei-bing, WU Jian-quan, GAO Lan-xing (Institute of Hygiene and Evironmental Medicine, Academy of Military Medical Sciences, PLA, Tianjin 300050, China);Experimental Study on The Anti-Radiation Effect of Soybean Isoflavones[J];Amino Acids & Biotic Resources;2004-03
5 JIN LI-YING,GUO ZONG-JUN,CUI HONG-BO, et al(Institute of Cerebrovascular Diseases,Qingdao University Medical College,Qingdao 266003,China);OBSERVATION OF ESTROGEN RECEPTOR α IN DIFFERENT CEREBRAL REGIONS IN OVARIECTOMIZED RATS[J];Acta Academiae Medicinae Qingdao Universitatis;2006-01
6 ZHANG Shun-Li WEI Ji-Dong ZHANG Wen-Xue XU Cun-Shuan (College of Life Sciences, Henan Normal University, Henan Bioengineering Key Laboratory, Xinxiang 453002, Henan, China);Expression of HSP70 in early pregnant mouse uteri and effect of estrogen on its synthesis[J];Acta Zoologica Sinica;2003-03
7 Zhao Jihong 1) Liang Yu 2) Yan dayu 2) (1)College of Basic Sci., North China Univ. of Tech., 100041, Beijing, China 2) Graduate School of Univ. of Sci. &Tech. of China, 100039, Beijing, China);Structure-Antioxidation Relationship of Flavonoid Antioxidants[J];Journal of North China University of Technology;2001-01
8 Li Xinmin, Liu Shuzheng, Ma Xingyuan and Xu Jingda (Laboratory of Endocrinology, Department of Chemistry);A study of the effect of ginsenosides on the secretion of gonadotropins[J];;1988-04
9 Liu Jie, Yang Xu, Chen Zhcng, Liang Manyi, Li Jingluo(Dept,of Pharmacol,N. Bethune Univ.of Med.Sci;*Jilin Prouincial Institute of Silkworm Breeding);The calmative and sex hormone-like effect of Cordyceps militaris(L)Link(Cantherea pernyi)[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1994-01
10 GAO Min,WEI Li-hui △,SUN Peng-ming,WANG Jian-liu,ZHAO Dan,ZHAO Chao,WANG Zhi-qi(Department of Gynecology, Peking University People’s Hospital, Beijing 100044, China);Regulation of orphan receptor ERRα by estrogen and progesterone in endometrial carcinoma cell line[J];Journal of Peking University(Health Sciences);2005-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 AI Hao,XUE Xiaoou,NIU Jianzhao,et al.(Department of Obstetrics and Gynecology,The First Hospital Affiliated to Liaoning University,Liaoning 121001,China);Mechanism of ovary function impairing resulted from intraperitoneal injection of cisplatin[J];Chinese Journal of Clinical Obstetrics and Gynecology;2008-04
2 SUN Shuguang,LI Yujie,ZHANG Minghao Experimental Teaching Center,School of Basic Medicine,Henan University of Traditional Chinese Medicine,ZhengZhou 450008;Effect of Ligustrum Lucidum decoction on main organ coefficients of immature female mice[J];Journal of Zhengzhou University(Medical Sciences);2012-03
3 LIU Xiao-li,XUE Xiao-ou,TANG Bing-hua,NIU Jian-zhao(Dongzimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China);Effect of Daidzein on expression of fluorescein gene regulated by ERE in HEC-1B[J];Journal of Traditional Chinese Medicine University of Hunan;2011-01
4 AI Hao1,2,NIU Jian-zhao1#,XUE Xiao-ou3,LI Jian1 (1 Laboratory of cyto-bioch emistry,Beijing University of Chinese Medicine,Beijing 100029; 2 Department of Gynecology and Obstetrics,The First Hospital Affiliated to Liaoning Medical College;3 Dongzhimen Hospital,Beijing University of Chinese Medicine);Effects of genistein on ovary gene expression pattern of CDDP induced premature ovarian failure mice with syndrome of kidney and liver yin asthenia[J];Journal of Beijing University of Traditional Chinese Medicine;2008-07
5 LIU Xiao-li,XUE Xiao-ou,TANG Bin-hua,NIU Jian-zhao(Department of Gynecology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700);Influences of genistein on proliferation of HEC-1B and expressions of luciferase reporter genes[J];Journal of Beijing University of Traditional Chinese Medicine;2011-04
6 HU Yun-fei,ZHANG San-yuan (Dept of Obstetrics and Gynecology,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China;Effect of triptorelin acetate on endometrial adenocarcinoma HEC-1B cell[J];Journal of Shanxi Medical University;2009-03
7 YAN Jiong1,KONG Lin-ping2,LIU Hui3,XU Yan-wu3,MA Jing4,YU Xiao4,WU Bo-wei3(1Dept of Nutrition and Food Hygiene,School of Public Health,Shanxi Medical University,Taiyuan 030001,China;2Shanxi Province Mental Health Center;3Dept of Physiology,School of Basic Medical Science,Shanxi Medical University;4School of Public Health,Shanxi Medical University;);Effect of genistein pharmacological post-treatment on cardiomyocyte apoptosis and ultrastructure of myocardial tissue in rats with ischemia-reperfusion injury[J];Journal of Shanxi Medical University;2009-08
8 Mei JI1,Chao CHEN2,Liu-fang LIN1,Yu-huan LIU1,Zai-long CAI2,Chao-qin YU3(1.Department of Gynecology and Obstetrics,Changhai Hospital,Second Military Medical University,Shanghai,200433)(2.Clinical Research Center,Changhai Hospital,Second Military Medical University,Shanghai,200433)(3.Department of Chinese Traditional Medicine,Changhai Hospital,Second Military Medical University,Shanghai,200433);Influence of Phytoestrogen on Endometrium and Ectopic Endometrial Focus[J];Reproduction & Contraception;2012-03
9 LIU Wen-wen,XUE Ling(Shandong University of Traditional Chinese Medicine,Jinan 250355,China);Effect of Jingqianshu on ERβ Protein and Gene Expression in Rat Hippocampal Nearonal Cells[J];Lishizhen Medicine and Materia Medica Research;2010-09
10 LIU Xiao-li1,XUE Xiao-ou1,ZHAO Li-yun2,NIU Jian-zhao2(1.Department of Gynecology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;2.Institute of Basic Medical Science,Beijing University of Chinese Medicine,Beijing 100029,China);Effect of Daidzein on Proliferation of Endometrial Carcinoma and Its Mechanism[J];Chinese Journal of Information on Traditional Chinese Medicine;2011-10
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 XUE Xiaoou,NIU Jianzhao,WANG Jifeng. (The First Affiliated Hospital of Jinzhou Medical college,Jinzhou 121001,China );The significance and different expression of estrogen receptor subtypes in pre-and post-menopausal uterus[J];Chinese Journal of Clinical Obstetric and Gynecology;2003-04
2 XUE Xiao-ou, JIN Huan, NIU Jian-zhao, WANG Ji-feng (Beijing University of Chinese Traditional Medicine, Beijing 100029, China);Effects of Extracts of Root of Kudzu Vine on Mammary Gland and Uterus Development in Rats[J];China Journal of Chinese Materia Medica;2003-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved