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《Journal of Peking University(Health Sciences)》 2005-03
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Regulation of orphan receptor ERRα by estrogen and progesterone in endometrial carcinoma cell line

GAO Min,WEI Li-hui △,SUN Peng-ming,WANG Jian-liu,ZHAO Dan,ZHAO Chao,WANG Zhi-qi(Department of Gynecology, Peking University People’s Hospital, Beijing 100044, China)  
Objective:To explore the relationship between expression of ERRα mRNA and estrogen and progesterone and to elucidate the function of ERRα in endometrial carcinoma. Methods:The expression of ERRα mRNA was examined by reverse transcription polymerase chain reaction. Endometrial carcinoma cell line Ishikawa was dealt with different concentrations of 17β-estradiol(10 -10 mol/L,10 -8 mol/L and 10 -6 mol/L) for 15 min,30 min and 24 h and 17β-estradiol and ER inhibitor-ICI182780 were given concomitantly to observe the change of ERRα mRNA. Different concentrations of progesterone (10 -8 mol/L,10 -7 mol/L,10 -6 mol/L and 10 -5 mol/L)were also given to Ishikawa cell line for 24 h to observe the change of ERRα mRNA. Results:The expression level of ERRα mRNA was slightly higher than that of the control group after being stimulated for 15 min, 30 min and 24 h by 10 -10 mol/L 17β-estradiol. However the expression level of ERRα mRNA was significantly lower than that of the control group after being stimulated for 15 min, 30 min and 24 h by 10 -8 mol/L and 10 -6 mol/L of 17β-estradiol. When 10 -6 mol/L of ICI182780 and 10 -8 mol/L of 17β-estradiol were given simultaneously to Ishikawa cell line, this down-regulation was blocked. After being stimulated for 24 h by 10 -7 mol/L,10 -6 mol/L and 10 -5 mol/L of progesterone, the expression levels of ERRα mRNA were significantly higher than that of the control group, but no change was found in 10 -8 mol/L of progesterone. Conclusion:17β-estradiol can down-regulate the expression of ERRα mRNA and this regulation is mediated by estrogen receptor. Progesterone can up-regulate the expression of ERRα mRNA.
【Fund】: 国家自然科学基金(30371477)资助课题~~
【CateGory Index】: R737.33
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