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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 1994-S1
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STUDY ON THE TARGETING TREATMENT FOR CARDIOVASCULAR AND CEREBROVASCULAR DISEASES WITH LIPOSOME(Ⅱ)

Institute of Cardiovascular Research Zhang Lingzhi,et al  
In order to potentiate the targeting of cardiovascular and cerebrovascular drugs, liposomes were em-ployed as drug-carriers in the present experiments. Targeting liposomes were prepared by incorporating mannose,RGDS peptide(Arg-Gly-Asp-Ser,a ligand for the fibrinogen receptor on the platelet mem-brane),and alprenolol(a ligand for βreceptor).On the animal models, the tissue distribution of targeting li-posomes was studied.It was found that CGRP contents were remarkedly increased (P0.05 or P0.01) in cerebrospinal fluid and cerebral tissue by mannose modified liposomes encapsulating CGRP compared with by direct intravenously injection of CGRP. The content of liposomes modified with RGDS peptide was increased 17.5-fold in thrombi and was decreased 7.0-fold in liver compared with that of liposomes modified without RGDS peptide.Alprenolol-modified liposomes were mainly concentrated in heart and lung rich in beta-adren-ergic receptors.These results suggest that the targeting of liposomes for tissues and organs can be potentiat-ed through employing the receptors ligands as homing devices of liposomes and incorporating these ligands in-to liposomes.
【Fund】: 国家自然科学基金
【CateGory Index】: R459.9
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【References】
Chinese Journal Full-text Database 7 Hits
1 Institute of Cardiovascular Research Ling Shizhang,et al;STUDY ON TARGETING TREATMTNT FOR CARDIOVASCULAR AND CEREBROVASCULAR DISEASES WITH LIPOSOME(Ⅱ)[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1994-S1
2 Dilnur SHABITOFU,WANG Xiao Hong,LIU Nai Kui, ZHANG Ling Zhi,PENG Shi Qi,TANG Chao Shu (Institute of Cardiovascular Research, Beijing Medical University, Beijing 100083);Protective role of target liposome carried calcitonin gene related peptide in balloon denuded rat aorta[J];CHINESE PHARMACOLOGICAL BULLETIN;1998-04
3 XIA Cai-fu, LIU Jian-ping(China Pharmaceutical University,Nanjing 210009,China);Advances in Liposome Used as the Carriers of Cardio-Cerebral-Vascular Drug[J];Progress In Pharmaceutical Sciences;2004-03
4 PI Feng-mei,TU Xi-de,ZHOU Jian-pingSchool of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Recent development in ATP-loaded liposomes[J];Pharmaceutical and Clinical Research;2007-01
5 Xia Bing 1, Cui Ruiyao 1, Wang Xiaohong 1, Su Jialin 2, Li Xia 2, Tang Chaoshu 2 (1. Department of Pathophysiology of Medical College of Qingdao University\ 2. Cardiovascular Institute of Beijing Medical University);Role of Endothelin in Hypertensive Myocardial Hypertrophy of Rats[J];CHINESE JOURNAL OF HYPERTENSION;1997-03
6 LIANG Jian-Hui,XU Jun,ZHONG Nan-Shan.Guangzhou Institute of Respiratory Diseases,Guangzhou Medical College,Guangzhou 510120,China;A lungs-specific liposomal delivery system for gene therapy[J];Chinese Journal of Immunology;2004-02
7 Liu Jian;Liu Hanzhi;Chen Zhengqiu; Li Shumei;Shen Decheng (Institute of Hematology, CAMS and PUMC,Tianjin 300020);The Study of the Relationship between the Granule Size of Immunoliposomes and the Conjugate Ratio of F(ab')2 of McAb HI30(CD45)[J];ACTA ACADEMIAE MEDICINAE SINICAE;1995-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Lu Tianrun,Cao Xiaojian,Liu Jun,et al Department of Surgery,the First Affiliated Hospital of Nanjing Medical University,NanJing 210029;Pharmacokinetics research of ~(99m)Tc-NGF packed with liposome[J];Anhui Medical Journal;2004-01
2 HAN Xiao TAN Tian wei (College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China );New process for preparation of carboxymethyl-chitosan[J];JOURNAL OF BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY;2000-03
3 MA Ru HUANG Ming-zhi (College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China);Hydrolysis of chitosan with lysozyme[J];Journal of Beijing University of Chemical Technology;2002-06
4 Department of Pathophysiology Tang Chao-shu. et al;THE TARGETING OF MYOCYTE ANTIBODY COATED LIPOSOMES TO MYOCADIUM[J];;1988-06
5 Tang Chaoshu Department of pathophysiology;INTERACTION OF RAT CARDIOMYOCYTES WITH LIPOSOMES[J];;1991-04
6 Laboratory of Cardiovascuiar Pathophysioiogy Ling Shizhang,et al;STUDY ON TARGETING THROMBOLYSIS BY DRUG-GARRYINGLIPOSOMES MODIFIED WITY RGDS PEPTIDE[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1994-03
7 LI Shumin; HU Dayi; WANG Lihui;ZHENG Wei; PANG Yong zheng; SU Jingyi;et al(Department of Cardiology,The First Hospital,Beijing Medical University 100034);CHANGES IN ACTIVITY OF CARDIAC MITOGEN-ACTIVATED PROTEIN KINASE IN RATS WITH HYPERTENSION INDUCED MYOCARDIAL HYPERTROPHY[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1996-03
8 ZHAO Shu-min, MA Li-hui, LIU Sheng, et al(Department of Pathology, Chengde Medical College,Hebei Chengde 067000, China);EFFECTS OF MYOCARDIAL ISCHEMIA REPERFUSION ON MYOCARDIAL AND VASCULAR ENDOTHELIAL CELL ULTRASTURCUTURE IN RATS[J];Journal of Chengde Medical College;2004-04
9 L Luo 1,WEI Shao-min 1,LIN Hui-fen 1, LIU Yu-liang 1,YING Kang 2,MAO Yu-min 2(1.Research & Development Department of Shanghai Jahwa Co.LTD.,Shanghai 200082,C hina;2.State Key Laboratory of Genetic Engineering,Institute of Geneti cs,School of Life;Research advance of liposomes as transdermal drug delive ry carrier system[J];China Surfactant Detergent & Cosmetics;2002-05
10 ZHANG Shu-biao1, XU Ying-mei1, HU Jian-jun2, LIU Dong-liang2, QIAO Wei-hong2, LI Zong-shi2 (1.Department of Chemical Engineering Dalian Nationalities University, Dalian Liaoning 116600, China; 2.State Key Laboratory of Fine Chemicals Dalian University of Technology, Dalian Liaoning 116012, China);Fundamental Aspects of Liposomes[J];Journal of Dalian Nationalities University;2004-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LI Xin, HE Sheng, ZHANG Yun-shan (Department of Ultrasound,Naval General Hospital, Beijing 100037, China);The Experimental Study of Targeted Contrast Ultrasonography on Atherosclerosis of Abdominal Aorta in Rabbits[J];Journal of Naval General Hospital;2006-01
2 HUANG Zhi chun 1,ZHANG Li 1,LIU Feng qin 1,HAO Fu 2 (1.Department of cardiology and E.N.T.The Affiliated Hospital of Inner Mongolia Medical College Huhhot 010050 China;2.Department of Health,Inner Mongolia Huhhot 010020 China);The Relationship Between Left Ventricuiar Hypertrophy and Plasm Endothlin and Nitric Oxide in Essential Hypertension[J];Nei Moivgol Medical Journal;2002-01
3 Wang hai Dai hongnian Wang youfa. Biomedical Center of Wuhan Science & Tecbnology University Wuhan 430070;Genetic control and biomaterial's researches progress[J];Orthopaedil Biomechanics Maternials and Clinical Study;2004-06
4 Jiang Zhip-ing, Xiao Lizhong, Xu Xin ,et al. Yuebei Hospital, Shaoguan Guangdong ,512026;The effects of puerarin on left ventricular hypertrophy in essential hypertensive patients[J];Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease;2004-05
5 MA Yan-chao~1,CHANG Yun (1.Luoyang Normal College,Luoyang 471022 China;2.Institute of Sport Science. General Administration of Sport,BeiJing 100061,China);Development of Research on Effect of Endothalin on Cardiac Hypertrophy[J];Journal of Xi'an Institute of Physical Education;2004-03
6 Zhang Chang e' Dan Jian xin Deparment of Pathophysiology, Xianning Medical College,Xianning,437100;Effects of L-Arginine on the Endothelin in plasma and Local Angiotensin II in the hypertrophic heart in rats with renovascular hypertension[J];Chinese Journal of Cardiovascular Medicine;2002-04
7 NIU Rong li, XUE Hong xie, LI Zhi liang (Department of Parasitology, Xinjiang Medical University);Preparation of albendazole immunoliposome[J];Journal of Xinjiang Medical University;2001-01
8 Zhang Cang-e (Department of Pathophysiology,Xianning Medical College,Xianning Hubei,437100,China);The Effects of L-Arg on the Myocardial Hypertrophy in Rats with Renal Hypertension[J];Journal of Xianning Medical College;2002-03
9 WAHG Xiao Hong, OU He Sheng, FU Min Gui, LI Shu Lian, PANG Yong Zheng, TANG Chao Shu, LIU Nai Kui 1 (Institute of Cardiovascular Research, The First hospital, 1Institute of Cardiovasclar Basic Research, Beijing Medical University, Beijing;The effect of liposome encapsulated C type natriuretic peptide on vascular response[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-05
10 ZHANG Wen hua, XIA Dao zi, ZHANG Yu hong, QU Peng(Dept. Ultrasongraphy, Second Affiliated Hospital of Dalian Medical University, Dalian 116023 China);Atrial Natriuretic Peptide and Endothelin in Plasma and Myocardium in Renovascular Hypertensive Rats[J];Chinese Journal of Hypertension;2003-02
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