PRECONDITIONING PROTECTES INTESTINE FROM ISCHEMIC REPERFUSION INJURY OF RAT
LIU Xiuhua;PANG Yongzheng;SU Jingyi;TANG Chaoshu(Laboratory of Shock Pathophysiology,Institute of Cardiovascular Research,Beijing Medical University 100083)
bjective:To investigate the protection of ischemic preconditioning on intestinal I/R injury and its mechanism in rat.Metkods:On the model of intestinal I/R injury, Bp,intestinal tissue injury,and function of vasculature were observed and assayed.Each value was expressed as the x±s. statisti-cal analyses were performed with oneway ANOVA;Results:Preconditioning attenuated hemorrhage in intestinal mucoca and the decrease of systemic Bp.In the preconditioned animals,tissue MDA content and plasma LDH activity were significantly lower than those of the I/R group(P0.01).Intestinal Evans blue dye content and MPO activity were also significantly lower than those in the I/R group(P0.01).Couclusions:Ischemic preconditioning can protect intestine from I/R injury.The mechanism may be involved in the protection of intestinal vasculature.
【CateGory Index】： R574.505