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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 1996-03
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CHANGES IN ACTIVITY OF CARDIAC MITOGEN-ACTIVATED PROTEIN KINASE IN RATS WITH HYPERTENSION INDUCED MYOCARDIAL HYPERTROPHY

LI Shumin; HU Dayi; WANG Lihui;ZHENG Wei; PANG Yong zheng; SU Jingyi;et al(Department of Cardiology,The First Hospital,Beijing Medical University 100034)  
Objective:To study the pathway of intracellular signaling transduction in hypertension-in-duced myocardial hypertrophy,Methods:Male Wistar rats(120~140g,n=6)were randomly divided into two groups:(1)hypertension(H)rats induced by constriction of the abdominal aorta with high salt diet;(2)control(C)the same operation as the hypertension group, but not constricting the ab-dominal aorta and normal diet.After 30 days of operation,cardiac mitogen-activated protein kinase(MAPK)activity was observed by radioactivity of 32P. Data treatment was done by student't analysis and line-relatively logist. Results:There was a positive correlation between myocardial MAPK activity and blood pressure r=0.66,P0.05)and cardiac MAPK activity and left ventricular hypertrophy(r=0. 92,P 0.01) Conclusion: The pathway of intracellular signaling transduction in hypertension-induced myocardial hypertropy may involve MAPK system.
【CateGory Index】: R544.102
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